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Monoclonal Antibodies against Human Neurotrophin-3
Biochemical and Biophysical Research Communications, 1993Hybridomas producing monoclonal antibodies (MoAbs) against human neurotrophin-3 (hNT-3) were established using recombinant hNT-3 produced in CHO cells and E. coli as immunogens. Of the five MoAbs obtained, MoAb 3w3 showed the highest antibody titer and also best neutralized NT-3 activity as measured by the survival of chick embryonic day-8 dorsal root ...
K. Kuroshima +6 more
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Neurotrophin-3 modulates synaptic transmission
2020Neurotrophin-3 (NT-3) belongs to a family of growth factors called neurotrophins whose actions are centered in the nervous system. NT-3 is structurally related to other neurotrophins like brain-derived neurotrophic factor. The expression of NT-3 starts with the onset of neurogenesis and continues throughout life.
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Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Science, 1990The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and characterization of additional such factors has been impeded by their low abundance.
Maisonpierre, P.C. +6 more
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Apoptosis of Merkel cells in neurotrophin-3 null mice
Anatomy and Embryology, 2005Postnatal mice lacking neurotrophin-3 (NT3) are deficient in Merkel cells of touch domes and whisker follicles. We examined the mechanism of Merkel cell loss by immunocytochemistry and electron microscopy. Merkel cell of whisker follicles of NT3 null newborns exhibited decreased immunoreactivity for cytokeratin 8 and contained apoptotic bodies that ...
Milos Grim +3 more
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Neurotrophin‐3 signaling in mammalian Merkel cell development [PDF]
Developmental Dynamics, 2003 AbstractMerkel cells are sensory cells of neural crest origin. Because little is known about the mechanisms that direct their differentiation, we have investigated the potential role of a candidate regulatory factor, neurotrophin‐3 (NT‐3). At embryonic day 16.5 (E 16.5), neither NT‐3 nor its primary receptors, TrkC and p75NTR are expressed by Merkel ...
Milos Grim +4 more
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Dependence of developing group Ia afferents on neurotrophin‐3
Journal of Comparative Neurology, 1995AbstractAt birth, group Ia proprioceptive afferents and muscle spindles, whose formation is Ia afferent‐dependent, are absent in mice carrying a deletion in the gene for neurotrophin‐3 (NT‐3 –/–). Whether Ia afferents contact myotubes, resulting in the formation of spindles which subsequently degenerate, or whether Ia afferents and spindles never form ...
Jan Kucera +6 more
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Neurotrophin-3 as an essential signal for the developing nervous system [PDF]
Molecular Neurobiology, 1996 Rapid advances in characterization of the biological actions mediated by the third member of the neurotrophin family, neurotrophin-3 (NT-3), have been made recently in vitro as well as in situ. These have been made possible by the cloning of the genes for NT-3 and for its transducing receptor tyrosine kinase TrkC.
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Nature, 2008Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Hong-jun Yu +3 more
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Chapter 14 Neurotrophin—3 and Maintenance of Muscle Afferent Function
1999Publisher Summary Axotomizing peripheral cutaneous and muscle nerves and thus depriving them of contact with their peripheral targets result in slowed conduction of their action potentials. Reinnervation of their peripheral targets results in the recovery of conduction velocity.
John B. Munson +2 more
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Investigation of neuromuscular abnormalities in neurotrophin‐3‐deficient mice
European Journal of Neuroscience, 2009AbstractNeurotrophin‐3 (NT‐3) is a trophic factor that is essential for the normal development and maintenance of proprioceptive sensory neurons and is widely implicated as an important modulator of synaptic function and development. We have previously found that animals lacking NT‐3 have a number of structural abnormalities in peripheral nerves and ...
Lorryn Fisher +6 more
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