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Lack of association of schizophrenia with the neurotrophin‐3 gene locus
Acta Psychiatrica Scandinavica, 1995A case‐control association study was conducted among patients with schizophrenia (DSM‐III‐R, n= 141) and unaffected controls (n= 177) of Caucasain and African‐American ethnicity. No significant differences in the distribution of a dinucleotide repeat polymorphism in the neurotrophin‐3 (NT‐3) gene were noted between the two groups.
Vishwajit L. Nimgaonkar +4 more
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Specificity of neurotrophin-3 determined by loss-of-function mutagenesis
Journal of Neuroscience Research, 1997Neurotrophin-3 (NT-3) is a member of the family of neurotrophic factors, which also includes nerve growth factor (NGF) and which have specific activities on different subsets of vertebrate neurons. The aim of this study was to determine which residues in NT-3 direct its specificity to the cognate TrkC receptor.
Klas Kullander +2 more
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In vivo effects of neurotrophin-3 during sensory neurogenesis
Development, 1996ABSTRACT The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 are structurally related proteins regulating the number of neurons in peripheral ganglia of the nervous system. Increased levels of nerve growth factor or of brain-derived neurotrophic factor selectively prevent normally occurring ...
Ockel, M., Lewin, G. R., Barde, Y. A.
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Nerve growth factor antibodies recognize neurotrophin-3
Neurochemical Research, 1993The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the beta subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF.
Vincenza Corsa +3 more
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Neurotrophin-3 in the development of the enteric nervous system
2004To date, the only neurotrophin that has been shown to influence the development of the enteric nervous system (ENS) is neurotrophin-3 (NT-3). NT-3 plays an essential role in the development of both the neural-crest-derived peripheral nervous system and the central nervous system (i.e., Chalazonitis, 1996, Mol.
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Neurotrophin-3 gene polymorphisms and schizophrenia
Psychiatric Genetics, 1996It has been suggested on the basis of neuropathological and epidemiological evidence that schizophrenia is, at least in part, a neurodevelopmental illness. Some patients show abnormalities in cell position in the medial temporal lobes of their brains. Neurotrophin-3 is one of many proteins essential for the proper growth and development of the nervous ...
Gill, M +5 more
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Association of neurotrophin-3 gene variant with severe forms of schizophrenia
European Neuropsychopharmacology, 1995The recent possible neurodevelopmental etiology of schizophrenia makes neurotrophin-3 (NT-3) gene an interesting candidate locus for molecular study of schizophrenia. We searched DNA variants through the coding region and the AP-1 binding site of the NT-3 gene, and found three variants.
M. Hattori, S. Nanko
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Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons
Peptides, 2000In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance P or related tachykinin (SP/TK ...
DE GIORGIO, Roberto +3 more
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Neurotrophin-3 gene and schizophrenia
Schizophrenia Research, 1995Hajime Kazamatsuri +2 more
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Neurotrophin–3 knocks heart off Trk
Nature Medicine, 1996Deepak Srivastava, Eric N. Olson
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