Results 21 to 30 of about 16,647,982 (293)
Clinics, 2006 OBJECTIVE: For many years, it was believed that medullary regeneration could not occur, although currently there are many trials using neurotrophic factors, stem cells, fetal medulla grafts, peripheral nerve grafts, and antibodies against myelin ...
Douglas Kenji Narazaki +6 more
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Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
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Neurotrophin-3 signals redistribute RNA in neurons [PDF]
Proceedings of the National Academy of Sciences, 1997 The translocation of specific mRNAs to dendrites and their potential for locally regulated translation are likely to serve as an effector in neuronal plasticity. Whether translation in dendrites is regulated by delivery of the RNA to sites of plasticity or a stationary pool of localized RNA undergoes enhanced translational efficiency is not clear.
R B, Knowles, K S, Kosik
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TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
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Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]
Exploration of Drug ScienceProteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva +2 more
doaj +1 more source
Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]
, 1997 The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen +48 more
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Neurotrophin‐3 receptors in the developing chicken retina [PDF]
European Journal of Biochemistry, 1993 Neurotrophin 3 (NT‐3) had specific high‐affinity receptors (HNT‐3R) in the developing chick retina at all ages between embryonic day (E) 4 and E14. The affinity of HNT‐3R for 125I‐NT‐3 did not change with the developmental state. A dissociation constant (kd) of 13 pM was obtained.
Rodríguez-Tebar, Alfredo +2 more
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Frontiers in Cellular Neuroscience, 2014 BDNF and nitric oxide signaling both contribute to plasticity at glutamatergic synapses. However the role of combined signaling of both pathways at the same synapse is largely unknown.
Richard eKolarow +9 more
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Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
Scientific Reports, 2016 In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves.
Jun Suzuki, G. Corfas, M. Liberman
semanticscholar +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
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