Results 21 to 30 of about 1,885 (233)

Neurotrophin-3 accelerates reendothelialization through inducing EPC mobilization and homing

Open Life Sciences, 2020
Rapid endothelialization is an effective way to treat intimal hyperplasia after intravascular stent implantation. Blood vessels and nerves coordinate with each other in function, while neurotrophin-3 (NT-3) is an important class of nerve growth factors ...
Chen Yan, Cao Jian, Peng Weixia, Chen Wen   +3 more
doaj   +1 more source

Neurotrophin-3 Is Required for Appropriate Establishment of Thalamocortical Connections [PDF]

Neuron, 2002
In the vertebrate brain, the thalamus serves as a relay and integration station for diverse neuronal information en route from the periphery to the cortex. Formation of the thalamocortical tract occurs during pre- and postnatal development, with distinct thalamic nuclei projecting to specific cortical regions.
Luis F. Parada, Chikako Harada, Long Ma, Mario I. Romero, Susan K. McConnell, Jean M. Hébert, Takayuki Harada   +6 more
openaire   +3 more sources

Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]

Exploration of Drug Science
Proteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva, Polina Povarnina, Vladimir Dorofeev   +2 more
doaj   +1 more source

BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion

Frontiers in Cellular Neuroscience, 2014
BDNF and nitric oxide signaling both contribute to plasticity at glutamatergic synapses. However the role of combined signaling of both pathways at the same synapse is largely unknown.
Richard eKolarow, Richard eKolarow, Christoph eKuhlmann, Thomas eMunsch, Christoph eZehendner, Tanja eBrigadski, Tanja eBrigadski, Heiko J Luhmann, Volkmar eLessmann, Volkmar eLessmann   +9 more
doaj   +1 more source

Delivery of Neurotrophin-3 to the Cochlea using Alginate Beads [PDF]

Otology & Neurotology, 2005
The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening.NT-3 is a trophic growth factor that promotes the survival of the auditory nerve and may have a potential therapeutic role in slowing neuron loss in progressive deafness, especially as an adjunct ...
Noushi, Fanoosh, Richardson, Rachael T., Hardman, Jennifer, Clark, Graeme M., O'LEARY, STEPHEN   +4 more
openaire   +3 more sources

RNA sequencing dataset describing transcriptional changes in cervical dorsal root ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with an adeno-associated viral vector encoding human neurotrophin-3

Data in Brief, 2018
Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural ...
Claudia Kathe, Lawrence D.F. Moon
doaj   +1 more source

Effect of malignant growth and chronic neurogenic pain on neurotrophin levels in rat brain

Бюллетень сибирской медицины, 2021
Aim. Determination of neurotrophin levels in gray and white matter of the brain in rats with tumor growth associated with chronic neurogenic pain (CNP).Materials and methods. The study included white outbred male rats (n = 74). In the main group, the CNP
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, I. V. Neskubina, E. I. Surikova, I. M. Kotieva, L. K. Trepitaki   +7 more
doaj   +1 more source

Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression

Frontiers in Aging Neuroscience, 2017
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain is thought to play a causative role in the development of cognitive dysfunction in Alzheimer's disease.
Li An, Jingzhu Zhang, Rui Zhang, Rui Zhang, Zhipeng Zhan, Xinhui Li, Fuyuan Zhou, Aiping Xing, Congmin Jiang, Yanqiu Chen   +9 more
doaj   +1 more source

Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons [PDF]

Proceedings of the National Academy of Sciences, 2000
Neurotrophins influence the epigenetic shaping of the vertebrate nervous system by regulating neuronal numbers during development and synaptic plasticity. Here we attempt to determine whether these growth factors can also regulate neurotransmitter plasticity.
Georg Dechant, Harald Schnürch, Claude Brodski   +2 more
openaire   +3 more sources

A New Role for Neurotrophin-3 [PDF]

The American Journal of Pathology, 1998
Nervous system and hair follicle epithelium share a common ectodermal origin, and some neurotrophins (NTs) can modulate keratinocyte proliferation and apoptosis. Therefore, it is reasonable to ask whether NTs are also involved in hair growth control.
Botchkarev, V A, Welker, P, Albers, K M, Botchkareva, N V, Metz, M, Lewin, G R, Bulfone-Paus, S, Peters, E M, Lindner, G, Paus, R   +9 more
openaire   +4 more sources