Results 31 to 40 of about 1,885 (233)
MethodsX, 2020 Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery into the cochlea has shown great potential in protecting and repairing the sensory cells important for hearing.
Patrick Lam +7 more
doaj +1 more source
Neurotrophin‐3 targets the translational initiation machinery in oligodendrocytes [PDF]
Glia, 2009 AbstractNeurotrophin‐3 (NT‐3) regulates oligodendrocyte (OLG) differentiation by mechanisms that remain poorly understood. Exposure of OLGs to NT‐3 induces a significant increase in the levels of myelin basic protein (MBP). However, we found that this stimulation occurs in the absence of measurable effects on MBP gene promoter activation or mRNA ...
Carmen Sato-Bigbee +3 more
openaire +3 more sources
Frontiers in Neuroscience, 2017 Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the present work was to characterize the presence of neurotrophins in extraocular motoneurons and muscles of the adult rat.
Rosendo G. Hernández +5 more
doaj +1 more source
Neurotrophin-3 is increased in skin in human diabetic neuropathy [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1998 Neurotrophin-3 (NT-3), a member of the neurotrophin family, has been shown to be necessary for the development of muscle spindle and Merkel cell afferent nerve fibres in animal models. The presence of NT-3 in the suprabasal epidermis, where many unmyelinated sensory fibres terminate, has been shown for the first time.
R M Lindsay +6 more
openaire +3 more sources
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro +12 more
wiley +1 more source
Neurobiology of Disease, 2002 To explore the role of neurotrophin-3 (NT-3) during cerebral ischemia, NT-3-deficient brains were subjected to transient focal ischemia. Conditional mutant brains produced undetectable amounts of NT-3 mRNA, whereas the expression of the neurotrophin ...
Brian Bates +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li +8 more
wiley +1 more source
Advanced Science, EarlyView.This systematic scoping review explores conductive nanocomposite hydrogels for neural tissue engineering(NTE), focusing on composition, cellular interactions, and neural differentiation capabilities. The review synthesizes data from 125 studies, examining important features including commonly used materials, cell types, and differentiation strategies ...
Mohammad Moghaddasi +6 more
wiley +1 more source
Respiratory Research, 2010 Background Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs.
Elmberger Göran P +6 more
doaj +1 more source
Nature Communications, 2021 Activation of brown adipose tissue thermogenesis increases energy expenditure and promotes weight loss in mice. Here the authors identify neurotrophic factor neurotrophin 3 (NT-3) as an adipokine that regulates sympathetic nervous system growth and ...
Xin Cui +11 more
doaj +1 more source