Results 61 to 70 of about 16,647,982 (293)

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression

Respiratory Research, 2010
Background Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs.
Elmberger Göran P, Haugom-Olsen Helga, Kramar Marija, Grunewald Johan, Dagnell Charlotta, Eklund Anders, Olgart Höglund Caroline   +6 more
doaj   +1 more source

The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]

, 2018
AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G., Coskun, E., Erdoğan, Çağdaş, Ozkul, A., Sahin, B., Topcu, A., Yilmaz, A.   +6 more
core   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Study of acute toxicity of dimeric dipeptide mimetic of neurotrophin-3 in mice

Фармакокинетика и Фармакодинамика
Introduction. Low-molecular-weight mimetics of neurotrophin-3 (NT-3) are considered promising compounds for the development of novel drugs. One of the first stages in the preclinical studies of candidate drugs is the assessment of acute toxicity. The aim
I. V. Alekseev, I. A. Miroshkina, A. V. Sorokina, S. V. Alekseeva, A. V. Volkova, A. D. Zakharov, K. S. Kachalov, I. B. Tsorin, L. G. Kolik, A. D. Durnev   +9 more
doaj   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Dual-phase SilMA hydrogel: a dynamic scaffold for sequential drug release and enhanced spinal cord repair via neural differentiation and immunomodulation

Frontiers in Bioengineering and Biotechnology
IntroductionSpinal cord injury (SCI) is a severe central nervous system disorder that results in significant sensory, motor, and autonomic dysfunctions.
Ruizhi Zhang, Mingzhe Zhang, Mingzhe Zhang, Lu Chen, Linlin Jiang, Chenbo Zou, Na Li, Hengxing Zhou, Hengxing Zhou, Shiqing Feng, Shiqing Feng   +10 more
doaj   +1 more source

Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation [PDF]

, 2011
10.1186/1756-6606-4-1Molecular ...
Je, H.S., Ji, Y., Lu, B., Wang, Y., Wu, W., Yang, F.   +5 more
core   +2 more sources

Sp4-dependent repression of neurotrophin-3 limits dendritic branching [PDF]

Molecular and Cellular Neuroscience, 2009
Regulation of neuronal gene expression is critical to establish functional connections in the mammalian nervous system. The transcription factor Sp4 regulates dendritic patterning during cerebellar granule neuron development by limiting branching and promoting activity-dependent pruning.
Ramos B, Valin, Alvaro, Sun, Xinxin, Gill, Grace   +3 more
openaire   +4 more sources