Results 141 to 150 of about 38,429 (260)

The structures of the neurotrophin 4 homodimer and the brain‐derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk‐binding site [PDF]

, 1999
Robert Robinson, Senyon Choe, Czeslaw Radziejewski, Glen Spraggon, Jason Greenwald, M. Kostura, Leslie D. Burtnick, David I. Stuart, E. Yvonne Jones   +8 more
openalex   +1 more source

Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning

Cancer Medicine, Volume 14, Issue 13, July 2025.
By analyzing single‐cell transcriptomic data from 5 neuroblastoma patients with MYCN amplification and 7 patients without MYCN amplification (GSE21840), and applying machine learning approaches, we identified five candidate pathogenic genes potentially associated with MYCN amplification.
Jiasi Zhang, Yichen Lei, Yaqin Wang, Wen Yu, Xiaoyan Zhao, Yongbing Zhu, Dedong Zhang, Siying Liu, Aiguo Liu   +8 more
wiley   +1 more source

Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome

Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.
This study reveals that the loss of MeCP2 in Rett syndrome model mice disrupts prefrontal connectivity. Although early environmental enrichment helps mitigate behavioral deficits and restores hippocampal BDNF levels, it fails to reverse the altered prefrontal connectivity or prevent the prefrontal‐specific decline in BDNF.
Sofie Ährlund‐Richter, Jonathan Harpe, Giselle Fernandes, Ruby Lam, Mriganka Sur   +4 more
wiley   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, Volume 6, Issue 4, Page 1987-2010, July 2025.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source

Sympathetic neurons in neonatal rats require endogenous neurotrophin-3 for survival [PDF]

, 1995
Xin‐Fu Zhou, Ryan B. Rush
openalex   +1 more source

TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

Brain Neurotrophins and Plant Polyphenols: A Powerful Connection. [PDF]

Molecules
Fiore M, Terracina S, Ferraguti G.
europepmc   +1 more source

Neurotrophin 4 Is Required for the Survival of a Subclass of Hair Follicle Receptors [PDF]

, 1998
Cheryl L. Stucky, Thomas M. DeChiara, Ronald M. Lindsay, G.D. Yancopoulos, Martin Koltzenburg   +4 more
openalex   +1 more source

Understanding the Intersection Between Hormonal Dynamics and Brain Plasticity in Alzheimer's Disease: A Narrative Review for Implementing New Therapeutic Strategies

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Alzheimer's disease (AD), a chronic neurodegenerative disorder, is portrayed by neurocognitive decline in the structure and function of the human brain. Various factors are implicated in the pathogenesis to neuroplasticity alteration in the brain of an individual afflicted with AD.
Abir Ghosson, Fatima Soufan, Hussein Kaddoura, Elissa Fares, Olivier Uwishema   +4 more
wiley   +1 more source

Effects of Stress and Allopregnanolone on the Expression of Neurotrophins and TrkB Receptor in the Sheep Hippocampus. [PDF]

Int J Mol Sci
Misztal T, Młotkowska P, Marciniak E, Barszcz M, Osuch B, Gajewska A, Misztal A.   +6 more
europepmc   +1 more source