Results 201 to 210 of about 38,974 (303)

TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis. [PDF]

Int J Biol Sci
Chang Y, Kong K, Qiao H, Jin M, Wu X, Fan W, Zhang J, Qi Y, Xu Y, Qin A, Zhai Z, Li H.   +11 more
europepmc   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose, Stone Sima, Neha Chopra, Ashish Diwan, Zi Gu   +4 more
wiley   +1 more source

BDNF/proBDNF Interplay in the Mediation of Neuronal Apoptotic Mechanisms in Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Mitrovic M, Selakovic D, Jovicic N, Ljujic B, Rosic G.   +4 more
europepmc   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Cord Blood Exosomal miRNAs from Small-for-Gestational-Age Newborns: Association with Measures of Postnatal <i>Catch-Up</i> Growth and Insulin Resistance. [PDF]

Int J Mol Sci
Díaz M, Quesada-López T, Villarroya F, López-Bermejo A, de Zegher F, Ibáñez L, Casano-Sancho P.   +6 more
europepmc   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

From Brain to Insomnia: Can Neurotrophic Factors Unlock the Sleep Puzzle After Stroke? [Response To Letter]. [PDF]

Nat Sci Sleep
Shi G, Wang X, Zhou R.
europepmc   +1 more source

Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications

MedComm, Volume 6, Issue 9, September 2025.
This graphical abstract summarizes the effects of ionizing radiation (IR) on epithelial–mesenchymal transition (EMT), emphasizing critical processes such as DNA damage repair, tumor microenvironment interactions, and resistance mechanisms. It highlights EMT‐induced radioresistance regulators, such as TGF‐β, Wnt, Notch, ERK, and various miRNAs, as well ...
Dhasarathdev Srinivasan, Ranjith Balakrishnan, Ankush Chauhan, Jeevan Kumar, Dinesh Murugan Girija, Reena Shrestha, Rupendra Shrestha, Rajasekaran Subbarayan   +7 more
wiley   +1 more source

Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia. [PDF]

Cancers (Basel)
de Andrade KP, Michaelsen GL, Dutra LF, Marques RF, Benincasa DER, Portich JP, Loss JF, Gregianin LJ, Brunetto AT, Sinigaglia M, Roesler R, da Cunha Jaeger M, Land M, de Farias CB.   +13 more
europepmc   +1 more source

Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
This study examined the impact of confounding factors on gene expression in postmortem brain tissue from individuals with psychiatric disorders. The expression was significantly associated with factors such as pH, RIN, PMI, and storage duration, highlighting the importance of accounting for these variables when interpreting transcriptomic data ...
Masataka Hatano, Atsuko Nagaoka, Kazusa Miyahara, Yuto Hosogai, Risa Shishido, Hideomi Hamasaki, Mizuki Hino, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii, Itaru Miura   +10 more
wiley   +1 more source