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The skinny on neurotrophins [PDF]
Nature Neuroscience, 2003 Brain-derived neurotrophic factor (BDNF) is best known as a regulator of brain development and plasticity. New evidence suggests that BDNF is also a component of the hypothalamic melanocortin pathway that controls body weight in adults.
Michael W. Schwartz, Brent E. Wisse
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Acupuncture and Neurotrophin Modulation
2013The Western explanation for acupuncture effectiveness is based upon more than half a century of basic and clinical research, which identified the activation of sensory system and the subsequent activity-dependent regulation of neurotransmitters, neurohormones, and several classes of neuromodulators as plausible mechanism for the acupuncture's ...
SOLIGO, Marzia +4 more
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2014
There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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Neurotrophin and Neurotrophin Receptor Protein Expression in the Human Lung
American Journal of Respiratory Cell and Molecular Biology, 2004Neurotrophins (NTs) promote survival and differentiation of central and peripheral neurons, and display several activities also in non-neuronal cells. Human lungs synthesize and release NTs, which are probably involved in the pathophysiology of pulmonary disturbances.
RICCI, Alberto +8 more
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Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease
Journal of Pediatric Surgery, 1996Interactions of the trk family of tyrosine kinase receptors with neurotrophins promote growth and differentiation of nervous-system cells during development. Disturbances in neurotrophic signalling could be involved in functional or aganglionic conditions of the intestine such as Hirschsprung's disease (HD).
Jeff C Hoehner +3 more
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Current Opinion in Neurobiology, 1994
The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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2006
The neurotrophins are homodimeric polypeptide growth factors that regulate the development and functioning of neurons and other cell types. Nerve growth factor (NGF) is the prototype. It is synthesized as a precursor pro-NGF that is further processed to a mature polypeptide, and each form has distinct activities.
Ljubica Ivanisevic, H. Uri Saragovi
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The neurotrophins are homodimeric polypeptide growth factors that regulate the development and functioning of neurons and other cell types. Nerve growth factor (NGF) is the prototype. It is synthesized as a precursor pro-NGF that is further processed to a mature polypeptide, and each form has distinct activities.
Ljubica Ivanisevic, H. Uri Saragovi
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Neurotrophin-4: The odd one out in the neurotrophin family
Neurochemical Research, 1996Neurotrophin-4 (NT-4) is a member of a family of neurotrophic factors, the neurotrophins, that control survival and differentiation of vertebrate neurons (2-4). Besides being the most recently discovered neurotrophin in mammals, and the least well understood, several aspects distinguish NT-4 from other members of the neurotrophin family. It is the most
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Neurotrophins and neurotrophin antagonists as potential therapeutics
Restorative Neurology and Neuroscience, 1995John W. Winslow +3 more
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