Results 21 to 30 of about 55,877 (286)

Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot–Marie–Tooth 2B Disease

Biomolecules, 2023
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
doaj   +1 more source

Recent advances in understanding neurotrophin signaling

F1000Research, 2016
The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of biological functions.
M. Bothwell
semanticscholar   +1 more source

Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor

Frontiers in Molecular Neuroscience, 2022
Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation.
Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao   +18 more
doaj   +1 more source

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

Journal of Neuroscience, 1995
Chronic stress produces structural changes and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons ...
Mark A. Smith, Shinya Makino, R. Kvetňanský, Robert M. Post, Psy-Chiatry Branch   +4 more
semanticscholar   +1 more source

The p75 neurotrophin receptor: at the crossroad of neural repair and death

Neural Regeneration Research, 2015
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation
R. Meeker, Kimberly S Williams
semanticscholar   +1 more source

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Biomedicines, 2022
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos   +15 more
doaj   +1 more source

Mechanisms and regulation of neurotrophin synthesis and secretion

Neurosciences, 2016
Neurotrophins are secreted proteins that are synthesized as pre-pro-neurotrophins on the rough endoplasmic reticulum, which are subsequently processed and then secreted as mature proteins.
Mohammad A. Al-Qudah, Ahmed Al-Dwairi
semanticscholar   +1 more source

Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

Biomolecules, 2019
The spatial and temporal availability of cytokines, and the microenvironments this creates, is critical to tissue development and homeostasis. Creating concentration gradients in vitro using soluble proteins is challenging as they do not provide a self ...
Yuka Matsuzaki, Rina Maruta, Keiko Takaki, Eiji Kotani, Yasuko Kato, Ryoichi Yoshimura, Yasuhisa Endo, Ciara Whitty, Christian Pernstich, Raj Gandhi, Michael Jones, Hajime Mori   +11 more
doaj   +1 more source

Oxytocin/Osteocalcin/IL-6 and NGF/BDNF mRNA Levels in Response to Cold Stress Challenge in Mice: Possible Oxytonic Brain-Bone-Muscle-Interaction

Frontiers in Physiology, 2019
Oxytocin (Oxt), osteocalcin (Ost), and NGF/BDNF have a role in bone homeostasis, reproduction, and cognition. Oxt/Ost is required for muscle repair. We investigated gene response of muscle and the inter-organ communication following cold stress (CS). The
Claudia Camerino, Elena Conte, Maria Rosaria Carratù, Adriano Fonzino, Marcello Diego Lograno, Domenico Tricarico   +5 more
doaj   +1 more source

Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin*

Journal of Biological Chemistry, 2015
Background: Although polySia is known to retain neurotrophins, their releasing mechanism remains unknown. Results: PolySia present on the cell surface of microglia is rapidly cleared by Neu1 sialidase on exovesicles secreted upon inflammatory stimulus ...
Mizuki Sumida, Masaya Hane, U. Yabe, Y. Shimoda, O. Pearce, M. Kiso, T. Miyagi, M. Sawada, A. Varki, K. Kitajima, C. Sato   +10 more
semanticscholar   +1 more source