Results 41 to 50 of about 35,168 (213)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Effects of continuous and interval training on brain-derived neurotrophic factor concentrations and executive function in physically inactive adolescents with overweight and obesity

Frontiers in Adolescent Medicine
IntroductionThis study aimed to analyze the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the plasma concentrations of brain-derived neurotrophic factor (BDNF) and executive function in physically
Francisco José de Menezes-Junior, Caroline Brand, Maiara Cristina Tadiotto, Tatiana Aparecida Affornali Tozo, Patricia Ribeiro Paes Corazza, Jorge Mota, Beatriz Pereira, Rafaela Rosário, Rafaela Rosário, Neiva Leite, Neiva Leite, Neiva Leite   +11 more
doaj   +1 more source

Plasma Levels of Brain-Derived Neurotrophic Factor and S100B in Relation to Antidepressant Response to Ketamine

Frontiers in Neuroscience, 2021
BackgroundEvidence demonstrates that brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100B) have a pivotal role in the pathogenesis of major depressive disorder (MDD) and they are proposed as predictors of antidepressant ...
Haitang Jiang, Haitang Jiang, Emma R. Veldman, Mikael Tiger, Carl-Johan Ekman, Johan Lundberg, Per Svenningsson   +6 more
doaj   +1 more source

Neurotrophin and Neurotrophin Receptors in Human Fetal Kidney

Developmental Biology, 1996
Vertebrate kidney development involves a series of complex interactions between the ureteric bud and undifferentiated mesenchyme resulting in the production of the nephron unit. These interactions are thought to be dependent on a variety of locally derived soluble factors, including peptide growth factors and their receptors.
Huber, L.Julie, Hempstead, Barbara, Donovan, Michael J.   +2 more
openaire   +2 more sources

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Irisin, Brain-Derived Neurotrophic Factor (BDNF), and Redox Balance in Geriatric Dynapenia

Antioxidants
Irisin and brain-derived neurotrophic factor (BDNF) are considered potential biomarkers for sarcopenia; however, their interplay and relationship with oxidative stress remain unclear. Therefore, the aim of this study was to assess the serum concentration
Aleksandra Wojszel, Jakub Śliwowski, Justyna Rentflejsz, Joanna Rogalska, Małgorzata Michalina Brzóska, Zyta Beata Wojszel   +5 more
doaj   +1 more source

Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration

Frontiers in Cellular Neuroscience, 2019
Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT receptors.
Horacio Uri Saragovi, Horacio Uri Saragovi, Horacio Uri Saragovi, Alba Galan, Alba Galan, Leonard A. Levin, Leonard A. Levin, Leonard A. Levin   +7 more
doaj   +1 more source

Plasma BDNF and TrkB mRNA in PBMCs Are Correlated With Anti-depressive Effects of 12-Weeks Supervised Exercise During Protracted Methamphetamine Abstinence

Frontiers in Molecular Neuroscience, 2020
Purpose: The aim of this study was to evaluate the potential neurotrophic factors and expression of neurotrophin receptors in peripheral blood mononuclear cells linked with the antidepressant action of exercise intervention during protracted ...
Jue Yang, Jue Yang, Jun Tan, Lan Zheng, Chun Xia Lu, Wen Qi Hou, Yi Liu, Qiu Fang Li, Jin Xiu Li, Dan Cheng, Xu Luo, Jun Zhang   +11 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source