Results 61 to 70 of about 66,390 (268)

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Organic electrode coatings for next-generation neural interfaces [PDF]

, 2014
Traditional neuronal interfaces utilize metallic electrodes which in recent years have reached a plateau in terms of the ability to provide safe stimulation at high resolution or rather with high densities of microelectrodes with improved spatial ...
Abidian, Abidian, Abidian, Abidian, Ahearne, Ahmed, Allen, Almany, Andrade, Andrew J. Woolley, Anseth, Aouada, Asplund, Aymard, Babcock, Baek, Baek, Baker, Banati, Banerjee, Banker, Barras, Barrese, Barros, Bartlett, Bhatheja, Bianco, Bidez, Biran, Blau, Bloch, Bolin, Boretius, Bottini, Brummer, Burdick, Campbell, Capadona, Chan, Chen, Cheung, Chikar, Cogan, Cogan, Cogan, Collier, Collinger, Cui, Cui, Cui, Cui, Daud, David-Pur, De Volder, DeLong, Drury, Evans, Fan, Fieberg, Fine, Fitch, Fitch, Fonner, Fujita, Gabay, Geddes, Georgakilas, George, Georges, Gillespie, Gilmour, Green, Green, Green, Green, Green, Green, Green, Green, Green, Green, Green, Guimard, Gumbiner, Haghighi, Hallab, Hascup, Hassarati, Hassler, He, Heim, Higashimori, Hoffman, Houweling, Hsu, Huang, Humayun, Jain, Jhaveri, Johnson, Kagan, Keefer, Kim, Kim, Kim, Kim, Kim, Kim, Krishnan, Kurisawa, Labaye, Lacour, Laura A. Poole-Warren, LaVan, Leach, Lee, Lee, Lee, LeRoux, Letherby, Li, Li, Lim, Lim, Lin, Liu, Lozano, Lu, Ludwig, Ludwig, Luo, Luo, Luo, Ma, Mahadevappa, Majumdar, Mao, Mario Cheong, Martin, Matsumoto, McConnell, McCreery, McCreery, Merker, Merrill, Nakayama, Nguyen-Vu, Nguyen-Vu, Nicodemus, Nigel H. Lovell, Niina, Nilasaroya, Normand, Normann, Novikova, Ochiai, Ochiai, Ouyang, Peixoto, Perlmutter, Piantino, Polikov, Poole-Warren, Rao, Raub, Richardson, Richardson, Richardson-Burns, Richter, Richter, Rosario-Canales, Rose, Rousche, Runge, Rylie A. Green, Sarah, Schmidt, Schuettler, Schuettler, Seidlits, Shannon, Shepherd, Shoval, Sidhu, Stauffer, Stevenson, Suri, Suzuki, Taylor, Telford, Tian, Turner, Tyler, Ulises A. Aregueta-Robles, Vaquette, Wadhwa, Wang, Ward, Webster, Weldon, Wells, Wester, White, Whitney, Wilks, Willerth, Wilson, Winter, Winter, Woolley, Xiao, Xiao, Yamato, Yang, Yang, Yang, Yu, Yu, Zhong, Zhong, Zhong, Zhong, Zuidema   +222 more
core   +2 more sources

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]

, 2009
A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor, Blesch, Armin, Conner, James M, Havton, Leif A, Hollis, Edmund R, Tuszynski, Mark H   +5 more
core   +2 more sources

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Neurotrophins

Kocatepe Veterinary Journal, 2014
Nörotrofinler, nöronların sağkalımını ve fonksiyonlarını etkileyen, sinaptik fonksiyonu ve sinaptik plastisiteyi kontrol eden polipeptid yapılı büyüme faktör ailesidir. Nörotrofin ailesi üyeleri, sinir büyüme faktörü, beyin kaynaklı nörotrofik faktör, nörotrofin-3, nörotrofin-4/5, nörotrofin-6, ve nörotrofin7’dir.
KAZAK, Filiz, YARIM, Gül Fatma
openaire   +4 more sources

Plasma Levels of Brain-Derived Neurotrophic Factor and S100B in Relation to Antidepressant Response to Ketamine

Frontiers in Neuroscience, 2021
BackgroundEvidence demonstrates that brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100B) have a pivotal role in the pathogenesis of major depressive disorder (MDD) and they are proposed as predictors of antidepressant ...
Haitang Jiang, Haitang Jiang, Emma R. Veldman, Mikael Tiger, Carl-Johan Ekman, Johan Lundberg, Per Svenningsson   +6 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration

Frontiers in Cellular Neuroscience, 2019
Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT receptors.
Horacio Uri Saragovi, Horacio Uri Saragovi, Horacio Uri Saragovi, Alba Galan, Alba Galan, Leonard A. Levin, Leonard A. Levin, Leonard A. Levin   +7 more
doaj   +1 more source