Results 71 to 80 of about 35,168 (213)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
The role of neurotrophic factors in retinal ganglion cell resiliency
Frontiers in Cellular NeuroscienceMany retinal diseases are characterized by direct or indirect retinal ganglion cell (RGC) neurodegeneration. In glaucoma and optic nerve neuropathies, RGCs are the primary affected cells, whereas in photoreceptor dystrophies, RGC loss is secondary to the
Alan K. Abraham +3 more
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core pathophysiological framework of major depressive disorder, one of the leading causes of disability worldwide. Chronic stress is a major
Paola Brivio +11 more
wiley +1 more source
Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells
Bangladesh Journal of Pharmacology, 2014 In the present study, fluorophenyl retinoic acid triazole, a retinoic acid derivative having more bioavailability compared to the parent retinoic acid was investigated against cell growth and proliferation.
Hui Shi +4 more
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Neurobiology of Disease, 2001 We examined whether brain damage after focal cortex trauma may be attenuated by adenoviral delivery of the glial cell line-derived neurotrophic factor (GDNF) gene.
Dirk M. Hermann +4 more
doaj +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Background The bioactive molecules released from dentine are key to stem‐cell recruitment, proliferation and differentiation in regenerative endodontics. However, there is limited and conflicting information regarding current and potential agents for releasing dentine bioactive molecules for regenerative endodontic procedures.
Arwa Al‐Maswary +4 more
wiley +1 more source
Frontiers in Physiology, 2017 Brain-derived neurotrophic factor (BDNF) is a major orchestrator of exercise-induced brain plasticity and circulating (peripheral) BDNF may have central effects.
Jeremy J. Walsh +3 more
doaj +1 more source
Journal of Periodontal Research, EarlyView.A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed +6 more
wiley +1 more source
NT-4 Gene Expression of Male Wistar Rat’s Sciatic Nerve Fiber: The Effect of Decreased Activity on the Form of Spinal Nerve Ligation [PDF]
Journal of Advanced Biomedical Sciences, 2015 Background & Objectives: Painful neuropathy is a state resulting from somatosensory disease or injury. Neurotrophins such as NT-4 are crucial for neural growth and development and protect the integrity of function and structure of nervous system.
M Rahmati +4 more
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