Results 21 to 30 of about 35,168 (213)

Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot–Marie–Tooth 2B Disease

Biomolecules, 2023
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
doaj   +1 more source

Neuroplasticity and depression

Psychiatry and Clinical Psychopharmacology, 2021
The monoamine hypothesis claims that depression is a result of deficiency of serotonin and/or noradrenaline in the neuronal synapses of the central nervous system.
Dilek Gürpınar, Almıla Erol, Levent Mete   +2 more
doaj  

Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor

Frontiers in Molecular Neuroscience, 2022
Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation.
Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao   +18 more
doaj   +1 more source

Activation of Trk neurotrophin receptors in the absence of neurotrophins [PDF]

Proceedings of the National Academy of Sciences, 2001
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades.
F S, Lee, M V, Chao
openaire   +2 more sources

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Biomedicines, 2022
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos   +15 more
doaj   +1 more source

Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy

PLoS ONE, 2013
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M., Mohammad, Ghulam, De Hertogh, Gert, Nawaz, Mohd Imtiaz, Van Den Eynde, Kathleen, Siddiquei, Mohammad Mairaj, Struyf, Sofie, Opdenakker, Ghislain, Geboes, Karel   +8 more
openaire   +4 more sources

Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

Biomolecules, 2019
The spatial and temporal availability of cytokines, and the microenvironments this creates, is critical to tissue development and homeostasis. Creating concentration gradients in vitro using soluble proteins is challenging as they do not provide a self ...
Yuka Matsuzaki, Rina Maruta, Keiko Takaki, Eiji Kotani, Yasuko Kato, Ryoichi Yoshimura, Yasuhisa Endo, Ciara Whitty, Christian Pernstich, Raj Gandhi, Michael Jones, Hajime Mori   +11 more
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Oxytocin/Osteocalcin/IL-6 and NGF/BDNF mRNA Levels in Response to Cold Stress Challenge in Mice: Possible Oxytonic Brain-Bone-Muscle-Interaction

Frontiers in Physiology, 2019
Oxytocin (Oxt), osteocalcin (Ost), and NGF/BDNF have a role in bone homeostasis, reproduction, and cognition. Oxt/Ost is required for muscle repair. We investigated gene response of muscle and the inter-organ communication following cold stress (CS). The
Claudia Camerino, Elena Conte, Maria Rosaria Carratù, Adriano Fonzino, Marcello Diego Lograno, Domenico Tricarico   +5 more
doaj   +1 more source

Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

Cells, 2020
Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell invasion, and therapy resistance. EMT is regulated by transcription factors such as the protein products of the SNAI gene family, which inhibits the expression of ...
József Dudás, Andrea Ladányi, Julia Ingruber, Teresa Bernadette Steinbichler, Herbert Riechelmann   +4 more
doaj   +1 more source