Neurotrophin‐3 receptors in the developing chicken retina [PDF]
European Journal of Biochemistry, 1993 Neurotrophin 3 (NT‐3) had specific high‐affinity receptors (HNT‐3R) in the developing chick retina at all ages between embryonic day (E) 4 and E14. The affinity of HNT‐3R for 125I‐NT‐3 did not change with the developmental state. A dissociation constant (kd) of 13 pM was obtained.
Rodríguez-Tebar, Alfredo +2 more
openaire +4 more sources
Serum neurotrophin-3 and neurotrophin-4 levels are associated with asthma severity in children [PDF]
European Respiratory Journal, 2012 To the Editors: Asthma is the most common chronic disease in childhood and is characterised by chronic airway inflammation, reversible airflow obstruction and hyperresponsiveness of the airways. Among the substantial pathophysiological aspects of asthma are neuroimmune interaction mechanisms; neurotrophins are mediators of the interactions providing ...
Marta Rachel +7 more
openaire +2 more sources
Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J +8 more
core +1 more source
Production and characterization of recombinant mouse neurotrophin‐3 [PDF]
European Journal of Biochemistry, 1992 Neurotrophin‐3 (NT‐3) is a neurotrophic factor that has recently been cloned on the basis of its structural similarity to other members of the nerve growth factor (NGF) gene family. In order to produce this protein, a recombinant vaccinia virus containing the coding region for mouse NT‐3 was constructed. Conditioned medium harvested from cells infected
Gotz, R. +3 more
openaire +3 more sources
Crystallization and preliminary structural studies of neurotrophin‐3 [PDF]
Protein Science, 1994 AbstractNeurotrophin‐3 (NT‐3) has been crystallized in 2 forms. Orthorhombic crystals, space group P21212, diffracted to 2.8 Å and have cell dimensions a = 39.1 Å, b = 54.0 Å, and c = 65.5 Å. The second form is space group P43212, with cell dimensions a = b = 67.1 Å, and c = 107.9 Å. The tetragonal crystals diffract to 2.8 Å at room temperature and 2.5
Jennifer A. Kelly +3 more
openaire +3 more sources
The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity [PDF]
The Journal of Neuroscience, 1997 High-affinity neurotrophin-3 (NT3) receptors have been identified on nerve growth factor (NGF)-dependent sympathetic neurons, but their occupancy by NT3 does not lead to neuronal survival. The molecular nature of these NT3 binding sites was investigated in this study.
Dechant, G. +3 more
openaire +2 more sources
Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report
Balkan Medical Journal, 2015 Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching.
Onur İsmi +6 more
doaj +1 more source
A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]
, 2016 The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine +20 more
core +1 more source
Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia
Neural Regeneration Research, 2015 In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy.
Xu-yang Wang +8 more
doaj +1 more source
Effect of malignant growth and chronic neurogenic pain on neurotrophin levels in rat brain
Бюллетень сибирской медицины, 2021 Aim. Determination of neurotrophin levels in gray and white matter of the brain in rats with tumor growth associated with chronic neurogenic pain (CNP).Materials and methods. The study included white outbred male rats (n = 74). In the main group, the CNP
E. M. Frantsiyants +7 more
doaj +1 more source