Results 221 to 230 of about 58,898 (268)

Nerve growth factor antibodies recognize neurotrophin-3

Neurochemical Research, 1993
The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the beta subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF.
A, Negro, V, Corsa, S D, Skaper, L, Callegaro   +3 more
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Neurotrophin‐3 gene polymorphism associated with schizophrenia

Acta Psychiatrica Scandinavica, 1994
The recent possible neurodevelopmental etiology of schizophrenia makes the neurotrophin‐3 (NT‐3) gene an interesting candidate locus. We studied the allelic distributions of dinucleotide repeat polymorphism at the NT‐3 gene locus in 70 patients with schizophrenia and in 70 controls. A highly significant difference between the two groups was observed at
S, Nanko, M, Hattori, S, Kuwata, T, Sasaki, R, Fukuda, X Y, Dai, K, Yamaguchi, Y, Shibata, H, Kazamatsuri   +8 more
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Neurotrophin-3 modulates synaptic transmission

2020
Neurotrophin-3 (NT-3) belongs to a family of growth factors called neurotrophins whose actions are centered in the nervous system. NT-3 is structurally related to other neurotrophins like brain-derived neurotrophic factor. The expression of NT-3 starts with the onset of neurogenesis and continues throughout life.
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Neurotrophin-3 administration alters neurotrophin, neurotrophin receptor and nestin mRNA expression in rat dorsal root ganglia following axotomy

Neuroscience, 2007
In the months following transection of adult rat peripheral nerve some sensory neurons undergo apoptosis. Two weeks after sciatic nerve transection some neurons in the L4 and L5 dorsal root ganglia begin to show immunoreactivity for nestin, a filament protein expressed by neuronal precursors and immature neurons, which is stimulated by neurotrophin-3 ...
Kuo, L T, Groves, M J, Scaravilli, F, Sugden, D, An, S F   +4 more
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Neurotrophin-3 selectively increases cultured Purkinje cell survival

NeuroReport, 1994
Nerve growth factor (NGF) has been shown to promote the survival of cultured cerebellar Purkinje cells, when tested in conjunction with metabotropic receptor activation. In the present study, we examined the effects of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF).
H T, Mount, C F, Dreyfus, I B, Black
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Neurotrophin-3 deficient Schwann cells impair nerve regeneration

Experimental Neurology, 2008
Neurotrophin 3 (NT-3) is an important autocrine factor supporting Schwann cell (SC) survival and differentiation in the absence of axons. Prior studies have failed to define the explicit role of SC versus axon in NT-3 deficiency in relation to nerve regeneration and associated remyelination. In the paradigm we studied, using NT-3 heterozygous (NT3(+/-))
Zarife, Sahenk, Janet, Oblinger, Chris, Edwards   +2 more
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Sensory ganglia require neurotrophin-3 early in development

Development, 1994
ABSTRACT The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a mono-clonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neu-rotrophin-3 was initiated during completion of gangliogen-esis.
Gaese, F., Kolbeck, R., Barde, Y. A.
openaire   +3 more sources

Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats

Laboratory Investigation, 2020
Heterotopic ossification (HO) is a debilitating condition that results from traumatic injuries or genetic diseases, for which the underlying mechanisms remain unclear. Recently, we have demonstrated the expression of neurotrophin-3 (NT-3) and its role in promoting HO formation via mediating endothelial-mesenchymal transition (EndMT) of vascular ...
Jie, Zhang, Liang, Wang, Jun, Chu, Xiang, Ao, Tao, Jiang, , Bin Yan, Minjun, Huang, Zhongmin, Zhang   +7 more
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Neurotrophin–3 is required for proper cerebellar development

Nature Neuroscience, 1999
Neurotrophin–3 (NT–3) is a member of the neurotrophin family, which includes nerve growth factor (NGF), brain–derived neurotrophic factor (BDNF) and neurotrophin–4/5 (NT–4/5). These factors are crucial for development of the peripheral nervous system1, but not the central nervous system (CNS), except that NT–3 and BDNF have been implicated in the ...
B, Bates, M, Rios, A, Trumpp, C, Chen, G, Fan, J M, Bishop, R, Jaenisch   +6 more
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Neurotrophin‐3 signaling in mammalian Merkel cell development

Developmental Dynamics, 2003
AbstractMerkel cells are sensory cells of neural crest origin. Because little is known about the mechanisms that direct their differentiation, we have investigated the potential role of a candidate regulatory factor, neurotrophin‐3 (NT‐3). At embryonic day 16.5 (E 16.5), neither NT‐3 nor its primary receptors, TrkC and p75NTR are expressed by Merkel ...
Viktor, Szeder, Milos, Grim, Jan, Kucera, Maya, Sieber-Blum   +3 more
openaire   +2 more sources