Results 21 to 30 of about 58,898 (268)
Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
core +2 more sources
Neurotrophin-3 signals redistribute RNA in neurons [PDF]
Proceedings of the National Academy of Sciences, 1997 The translocation of specific mRNAs to dendrites and their potential for locally regulated translation are likely to serve as an effector in neuronal plasticity. Whether translation in dendrites is regulated by delivery of the RNA to sites of plasticity or a stationary pool of localized RNA undergoes enhanced translational efficiency is not clear.
R B, Knowles, K S, Kosik
openaire +2 more sources
Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth
Journal of Neuroinflammation, 2011 Pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) are considered to exert detrimental effects during brain trauma and in neurodegenerative disorders.
Boato Francesco +6 more
doaj +1 more source
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]
, 2011 Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María +4 more
core +4 more sources
eLife, 2016 Brain and spinal injury reduce mobility and often impair sensorimotor processing in the spinal cord leading to spasticity. Here, we establish that complete transection of corticospinal pathways in the pyramids impairs locomotion and leads to increased ...
Claudia Kathe +3 more
doaj +1 more source
Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]
, 1993 Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A. +4 more
core +3 more sources
Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]
Exploration of Drug ScienceProteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva +2 more
doaj +1 more source
Neurotrophin‐3 receptors in the developing chicken retina [PDF]
European Journal of Biochemistry, 1993 Neurotrophin 3 (NT‐3) had specific high‐affinity receptors (HNT‐3R) in the developing chick retina at all ages between embryonic day (E) 4 and E14. The affinity of HNT‐3R for 125I‐NT‐3 did not change with the developmental state. A dissociation constant (kd) of 13 pM was obtained.
Rodríguez-Tebar, Alfredo +2 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2014 BDNF and nitric oxide signaling both contribute to plasticity at glutamatergic synapses. However the role of combined signaling of both pathways at the same synapse is largely unknown.
Richard eKolarow +9 more
doaj +1 more source
Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]
, 2016 The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela +5 more
core +1 more source