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Neurotrophin signaling through the p75 neurotrophin receptor
Progress in Neurobiology, 2002The neurotrophins are growth factors that play critical roles in the development, maintenance, survival, and death of the nervous system. The signal transducing systems that mediate the diverse biological functions of the neurotrophins are initiated by their interactions with two categories of cell surface receptors, the Trk family of tyrosine kinases ...
Philippe P. Roux, Philip A. Barker
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2017
Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
Laís Bhering Martins +2 more
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Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
Laís Bhering Martins +2 more
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Progress in Neurobiology, 1994
The neurotrophins are members of a family of four related proteins that allow the survival and differentiation of specific sub-sets of embryonic vertebrate neurons. On neurons, two types of neurotrophin receptors can be distinguished on the basis of their dissociation constants: low affinity receptors (Kd 10(-9) M) and high affinity receptors (Kd 10 ...
G, Dechant +2 more
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The neurotrophins are members of a family of four related proteins that allow the survival and differentiation of specific sub-sets of embryonic vertebrate neurons. On neurons, two types of neurotrophin receptors can be distinguished on the basis of their dissociation constants: low affinity receptors (Kd 10(-9) M) and high affinity receptors (Kd 10 ...
G, Dechant +2 more
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Trends in Pharmacological Sciences, 1999
Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease
2000We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA.
Carolyn Rosenberg +6 more
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Acupuncture and Neurotrophin Modulation
2013The Western explanation for acupuncture effectiveness is based upon more than half a century of basic and clinical research, which identified the activation of sensory system and the subsequent activity-dependent regulation of neurotransmitters, neurohormones, and several classes of neuromodulators as plausible mechanism for the acupuncture's ...
SOLIGO, Marzia +4 more
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2014
There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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Neurotrophin and Neurotrophin Receptor Protein Expression in the Human Lung
American Journal of Respiratory Cell and Molecular Biology, 2004Neurotrophins (NTs) promote survival and differentiation of central and peripheral neurons, and display several activities also in non-neuronal cells. Human lungs synthesize and release NTs, which are probably involved in the pathophysiology of pulmonary disturbances.
RICCI, Alberto +8 more
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Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease
Journal of Pediatric Surgery, 1996Interactions of the trk family of tyrosine kinase receptors with neurotrophins promote growth and differentiation of nervous-system cells during development. Disturbances in neurotrophic signalling could be involved in functional or aganglionic conditions of the intestine such as Hirschsprung's disease (HD).
Jeff C Hoehner +3 more
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Experimental Cell Research, 2012
The neurotrophins - NGF, BDNF, NT-3 - are secreted proteins that play a major role in neuron survival, differentiation and axon wiring toward target territories. They do so by interacting with their main tyrosine kinase receptors TrkA, TrkB, TrkC and p75(NTR). Even though there is a general consensus on the view that neurotrophins are survival factors,
Ichim, Gabriel +2 more
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The neurotrophins - NGF, BDNF, NT-3 - are secreted proteins that play a major role in neuron survival, differentiation and axon wiring toward target territories. They do so by interacting with their main tyrosine kinase receptors TrkA, TrkB, TrkC and p75(NTR). Even though there is a general consensus on the view that neurotrophins are survival factors,
Ichim, Gabriel +2 more
openaire +4 more sources