Results 101 to 110 of about 1,167,955 (270)

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Immediate consecutive microvascular decompression for bilateral classical trigeminal neuralgia

Frontiers in Neurology
BackgroundClassical trigeminal neuralgia (TN) is characterized by sudden, severe facial pain, typically resulting from a neurovascular conflict affecting the trigeminal nerve.
Mauro Alberto Segura-Lozano, Mario Alexis del Real-Gallegos, Pedro Mendoza-Lemus, Octavio Carranza-Rentería, Yael Rodrigo Torres-Torres, Alejandro González-Silva, Arturo Santoyo-Pantoja, Aarón Giovanni Munguía-Rodríguez   +7 more
doaj   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

Advanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li, Zhikun Miao, Tuck‐Whye Wong, Tiefeng Li   +3 more
wiley   +1 more source

The outcomes of microvascular decompression for primary trigeminal neuralgia: insights from a single-center experience and technical advancements

Frontiers in Surgery
BackgroundMicrovascular decompression (MVD) remains the primary surgical treatment for trigeminal neuralgia due to its positive postoperative results. This study aims to evaluate the outcomes of patients with primary trigeminal neuralgia who underwent ...
Chingiz Nurimanov, Iroda Mammadinova, Karashash Menlibayeva, Assylbek Kaliyev, Yerbol Makhambetov, Serik Akshulakov   +5 more
doaj   +1 more source

elalilab/SupportingMaterial: Release version for "2024_Stroke_Pdgfrd"

<p>Release for the article "Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions" including rendered HTML file.</p ...
Laboratory of Neurovascular Interactions
core   +1 more source

"Why Do I Feel This Pain?" B-Mode and Power Doppler Ultrasound Found the Answer: A Neurovascular Conflict

, 2017
Neurovascular conflict (NC) represents a rare condition in which a nerve can be transiently compressed by vascular pulsations. This circumstance might cause pain and motor deficit. This particular condition is usually associated with anatomical variation
Piccinini, Giulia, Padua, Luca, Giovannini, Silvia   +2 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Beyond coincidence: a case series on the clinical course of coinciding cluster headache and short-lasting unilateral neuralgiform headache attacks

PAIN Reports
. Introduction:. Limited research has been conducted on co-occurring cluster headache and short-lasting unilateral neuralgiform headache attacks (SUNHA). Objectives:.
Julia J. Jansen, Job Scheurink, Tijmen Balvers, Rolf Fronczek, Wim M. Mulleners   +4 more
doaj   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

LepR‐Lineage Cells Represent the Main Target of the Nociceptive CGRP Pathway in White Adipose Tissue Browning

Advanced Science, EarlyView.
Regulation of WAT Browning and UCP1 Expression in LepR‐MSCs of Inguinal WAT by Nociceptive CGRP and Sympathetic Nervous System (SNS) Noradrenaline (NE). ABSTRACT Sympathetic innervation regulates white adipose tissue (WAT) browning; however, the roles of nociceptive neurons and their associated target cells remain unknown.
Yu‐Ting Yen, May Chien, Yan‐Tung Kiu, Ru‐Sing Lee, Hui‐Teng Cheng, Shuei‐Liong Lin, Dong‐Chuan Wu, I‐Hsien Teng, Yi‐Wen Lin, Yi‐Hung Chen, Mien‐Chie Hung, Shih‐Chieh Hung   +11 more
wiley   +1 more source