Results 71 to 80 of about 779,578 (304)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The forecasting performance of German stock option densities [PDF]

In this paper the authors estimate risk-neutral densities (RND) for the largest euro-area stock market (the index of which is the German DAX), reporting their statistical properties, and evaluating their forecasting performance.
Ben Craig, Martin Scheicher, Ernst Glatzer, Joachim Keller   +3 more
core   +2 more sources

Nightside Neutral Density Disturbances Collocated With Equatorial Plasma Irregularities Above 450 km: GRACE and GRACE‐FO Observations in 2002–2022

Space Weather
We investigate the climatology of Neutral Density Disturbances (NDDs) collocated with Equatorial Plasma Irregularities (EPIs) at altitudes above 450 km by using 20 years of data from the Gravity Recovery and Climate Experiment (GRACE) and GRACE‐FO ...
Hosub Song, Jaeheung Park, Chao Xiong, Jose van den IJssel, Daehee Lee, Jaejin Lee, Yu Yi   +6 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Testing the Forecasting Performance of Ibex 35 Option-implied Risk-neutral Densities [PDF]

Published also as: Documento de Trabajo Banco de España 0504/2005.risk-neutral densities, forecasting ...
Rubio Irigoyen, Gonzalo, Alonso, Francisco, Blanco, Roberto   +2 more
core  

The role of isotope mass on neutral fueling and density pedestal structure in the DIII-D tokamak

Nuclear Fusion
Experimental measurements on DIII-D of hydrogen neutral penetration lengths ( $\lambda_{n_0}$ ) on the high field side (HFS) are longer by a factor of $\sqrt{2}$ than for deuterium consistent with the thermal velocity ratio for neutrals at the same ...
R.A. Chaban, S. Mordijck, A.M. Rosenthal, A. Bortolon, J.W. Hughes, M. Knolker, F.M. Laggner, T.H. Osborne, L. Schmitz, K.E. Thome, T.M. Wilks   +10 more
doaj   +1 more source

Natural Cubic Spline Approximation of Risk-Neutral Density

International Journal of Financial Studies
The risk-neutral density is a fundamental concept in pricing financial derivatives, risk management, and assessing financial markets’ perceptions over significant political or economic events.
Shuang Zhou, Liyuan Jiang, Keren Li, Fangfang Wang, Jie Yang   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source