Results 71 to 80 of about 1,597,523 (296)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comprehensive and Open Assessment of Thermospheric Models During Geomagnetic Storm Times Within CCMC Framework

Space Weather
Thermospheric neutral density controls satellite drag in low Earth orbit and varies strongly during geomagnetic storms. We present a multi‐mission, phase‐resolved assessment of empirical and physics‐based thermosphere models using 151 storms from 2001 to
Jack C. Wang, Jia Yue, Sean Bruinsma, Masha Kuznetsova, Joseph Sypal, Richard Mullinix, Chiu Wiegand, Paul Dimarzio, Min‐Yang Chou, Maksym Petrenko, Christian Siemes, Sophie Laurens   +11 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Evaluation of TIEGCM based on GOCE neutral density

Frontiers in Physics
The Thermosphere Ionosphere Electrodynamic General Circulation Model (TIEGCM), as one of the most advanced physical models of the Earth’s thermosphere and ionosphere, is not only widely used in scientific research, but also has essential reference value ...
Zheng Li, Zheng Li, Jingjing Shao, Yan Wang, Jingyuan Li, Hua Zhang, Chunli Gu, Xiaojun Xu   +7 more
doaj   +1 more source

A Model for Neutral Defect Limited Electron Mobility in Strained-Silicon Inversion Layers

IEEE Journal of the Electron Devices Society, 2017
On the strained silicon metal-oxide-semiconductor field-effect transistors (MOSFETs), we show how to derive a formalism dealing with the scattering of a 2-D electron by a neutral defect.
Shang-Hsun Hsieh, Ming-Jer Chen
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Nightside Neutral Density Disturbances Collocated With Equatorial Plasma Irregularities Above 450 km: GRACE and GRACE‐FO Observations in 2002–2022

Space Weather
We investigate the climatology of Neutral Density Disturbances (NDDs) collocated with Equatorial Plasma Irregularities (EPIs) at altitudes above 450 km by using 20 years of data from the Gravity Recovery and Climate Experiment (GRACE) and GRACE‐FO ...
Hosub Song, Jaeheung Park, Chao Xiong, Jose van den IJssel, Daehee Lee, Jaejin Lee, Yu Yi   +6 more
doaj   +1 more source

The potential of tracing the star formation history with HI 21-cm in intervening absorption systems

, 2017
Unlike the neutral gas density, which remains largely constant over redshifts of 0 < z < 5, the star formation density exhibits a strong redshift dependence, increasing from the present day before peaking at a redshift of z ~ 2.5.
Curran, S. J.
core   +1 more source