Results 61 to 70 of about 779,578 (304)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Modelling the neutralisation process in neutral beam injectors [PDF]
, 2009 High power neutral beams currently play an important role in heating, fuelling and diagnosing magnetically confined thermonuclear fusion plasmas. At the Joint European Torus (JET) in Oxfordshire, England, the formation of such a beam involves passing a ...
Fitzgerald, Niall J.
core
, 2022 CO2 electrolysis to value-added products is a promising technology to close the carbon cycle and sequester anthropogenic CO2 into chemical feedstocks; an increase of the current density for multicarbon products is one of the requirements for practical ...
Asato, Inoue +3 more
core +1 more source
Space WeatherThermospheric neutral density controls satellite drag in low Earth orbit and varies strongly during geomagnetic storms. We present a multi‐mission, phase‐resolved assessment of empirical and physics‐based thermosphere models using 151 storms from 2001 to
Jack C. Wang +11 more
doaj +1 more source
, 2019 Citation: 'neutral-density filter' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.N04114 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Evaluation of TIEGCM based on GOCE neutral density
Frontiers in PhysicsThe Thermosphere Ionosphere Electrodynamic General Circulation Model (TIEGCM), as one of the most advanced physical models of the Earth’s thermosphere and ionosphere, is not only widely used in scientific research, but also has essential reference value ...
Zheng Li +7 more
doaj +1 more source
A Model for Neutral Defect Limited Electron Mobility in Strained-Silicon Inversion Layers
IEEE Journal of the Electron Devices Society, 2017 On the strained silicon metal-oxide-semiconductor field-effect transistors (MOSFETs), we show how to derive a formalism dealing with the scattering of a 2-D electron by a neutral defect.
Shang-Hsun Hsieh, Ming-Jer Chen
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source