Results 41 to 50 of about 1,597,523 (296)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Unusual Variation in Nitric Oxide Radiative Flux and Neutral Density Over Hunga‐Tonga Region Caused by the Volcanic Eruption

Geophysical Research Letters
Large‐scale volcanic eruptions, such as the Hunga‐Tonga volcanic eruption that occurred in 2022, can impact the atmospheric structure and dynamics in a highly complex way.
Dayakrishna Nailwal, M. V. Sunil Krishna, Xian Lu, Haonan Wu, Akash Kumar, Alok Kumar Ranjan   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Ionization structure in the winds of B[e] supergiants: I. Ionization equilibrium calculations in a H plus He wind

, 2003
The non-spherically symmetric winds of B[e] supergiants are investigated. An empirical density distribution is chosen that accounts for the density concentrations and ratios derived from observations, and our model winds are assumed to contain only ...
Allen, Bjorkman, Castor, Cohen, Drew, Drew, Gummersbach, H. J. G. L. M. Lamers, Humphreys, Ignace, Kraus, Kurucz, Lamers, Lamers, Leitherer, M. Kraus, MacFarlane, Magalhães, McGregor, McGregor, Nota, Owocki, Owocki, Pauldrach, Pauldrach, Pelupessy, Schulte-Ladbeck, Seaton, Thum, Thum, Vink, Voors, Zickgraf, Zickgraf, Zickgraf, Zickgraf, Zickgraf   +36 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Interhemispheric Asymmetry of the Thermospheric Neutral Density Response to the 7–9 September 2017 Geomagnetic Storms

Geophysical Research Letters, 2023
The thermospheric neutral density response to the 7–9 September 2017 storms is investigated based on the Swarm satellite observations and the thermosphere‐ionosphere‐electrodynamic general circulation model (TIEGCM) simulation.
Qingyu Zhu, Gang Lu, Jiuhou Lei, Yue Deng, Eelco Doornbos, Jose van denIJssel, Christian Siemes   +6 more
doaj   +1 more source

Density of neutral interstellar hydrogen at the termination shock from Ulysses pickup ion observations

, 2008
By reevaluating a 13-month stretch of Ulysses SWICS H pickup ion measurements near 5 AU close to the ecliptic right after the previous solar minimum, this paper presents a determination of the neutral interstellar H density at the solar wind termination ...
Auchère, Baranov, Baranov, Bertaux, Bertaux, Bzowski, Bzowski, Bzowski, Bzowski, Bzowski, Cheng, Costa, Cox, E. Möbius, Emerich, Fahr, Fahr, Frisch, G. Gloeckler, Gloeckler, Gloeckler, Gloeckler, Gloeckler, Gloeckler, Gloeckler, Gloeckler, Gloeckler, Harvey, Holzer, Issautier, Izmodenov, Izmodenov, Izmodenov, Izmodenov, Izmodenov, Izmodenov, Izmodenov, Izmodenov, King, Köhnlein, Lallement, Lindsay, M. Bzowski, Maher, Maksimovic, Marsch, McComas, McComas, McMullin, Möbius, Möbius, Möbius, Müller, Müller, Paresce, Phillips, Pilipp, Pilipp, Press, Pryor, Quémerais, Richardson, Rucinski, Rucinski, Rucinski, Rucinski, S. Tarnopolski, Salem, Slavin, Slavin, Tarnopolski, Thomas, Thomas, Tobiska, Tobiska, V. Izmodenov, Vallerga, Vasyliunas, Vidal-Madjar, Weller, Witte, Wolff, Woods   +82 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Recent progress on the retrieval and modeling of thermosphere mass density

地球与行星物理论评, 2023
The thermosphere is the atmospheric layer extending from about 90 km to nearly 1000 kilometers, which is an important interreaction area between the Sun and the Earth.
Jiuhou Lei, Ruoxi Li, Dexin Ren, Libin Weng, Haibing Ruan   +4 more
doaj   +1 more source