Results 51 to 60 of about 49,790 (212)

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells [PDF]

, 2014
Background: Hypoxia-induced genes are potential targets in cancer therapy. Responses to hypoxia have been extensively studied in vitro, however, they may differ in vivo due to the specific tumor microenvironment.
Gallé, B. (Birgit), Guelly, C. (Christian), Hofmann, N.A. (Nicole), Hrzenjak, A. (Andelko), Leithner, K. (Katharina), Lindenmann, J. (Jörg), Olschewski, A. (Andrea), Olschewski, H. (Horst), Philipsen, J.N.J. (Sjaak), Popper, H.H. (Helmut), Quehenberger, F. (Franz), Smolle-Jüttner, F.-M. (Freyja-Maria), Stacher, E. (Elvira), Stiegler, P. (Philipp), Wohlkoenig, C. (Christoph)   +14 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure [PDF]

, 2018
Objectives: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction.
Claggett, Brian, Damman, Kevin, Desai, Akshay S., Gori, Mauro, Jhund, Pardeep S., Lefkowitz, Martin P., McMurray, John J.V., Packer, Milton, Prescott, Margaret F., Rouleau, Jean L., Senni, Michele, Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +14 more
core   +4 more sources

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Effect of changed source/sink relations on proteolytic activities and on nitrogen mobilization in field-grown wheat (Triticum aestivum L.) [PDF]

, 2017
Nitrogen mobilization and the pattern of proteolytic enzymes were investigated in leaves and glumes of field-grown winter wheat (Triticum aestivum L.) during maturation. Source/sink relations were changed by removal of the ear, the flag leaf or the lower
Feller, Urs
core  

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

Differential expression of CD10 in prostate cancer and its clinical implication [PDF]

, 2007
BackgroundCD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate cancer; however, CD10 positive cancer cells frequently appear in ...
Dall'Era, Marc A, Liu, Alvin Y, Porter, Michael P, Sherertz, Tracy M, Siegel, Andrew F, True, Lawrence D   +5 more
core   +2 more sources

Proteomic Characterization of Grade II Furcation Defects: A Discovery‐Phase Study

Journal of Periodontal Research, EarlyView.
This study analyzed the gingival crevicular fluid (GCF) proteome of 35 patients with Grade II furcation defects using the Olink Reveal platform. Comparison with non‐periodontitis sites identified 227 differentially expressed proteins. A machine‐learning pipeline prioritized a 34‐protein signature (including GLIPR1, MME, and IRAG2) that accurately ...
Georgios S. Chatzopoulos, Dimitra Sakellari, Eleftherios G. Kaklamanos, Lazaros Tsalikis   +3 more
wiley   +1 more source

Changes in nitrogen contents and in proteolytic activities in different parts of field-grown wheat ears (Triticum aestivum L.) during maturation [PDF]

, 2017
Aminopeptidase, carboxypeptidase and neutral endopeptidase activities were analyzed in glumes and in kernels of field-grown wheat (Triticum aestivum L.) during ear development.
Feller, Urs
core  

Tomato plants control leaf sodium levels to limit damage by Spodoptera littoralis larvae

New Phytologist, Volume 250, Issue 5, Page 3417-3427, June 2026.
Summary Sodium is an essential element for animal growth and survival. Here we test the hypothesis that plants exposed to insect feeding can translocate sodium from the feeding site to other plant organs as a defense strategy against phytophagous insects, which need sodium in their diet.
Valerio Cirillo, Ilaria Di Lelio, Paola Punzo, Giovanni Jesu, Maria Giovanna De Luca, Marco Cepparulo, Claudio Russo, Nausicaa Pollaro, Antonio Marciano, Andrea Becchimanzi, Michael V. Mickelbart, Francesco Pennacchio, Albino Maggio   +12 more
wiley   +1 more source