Results 31 to 40 of about 49,790 (212)
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]
, 2019 Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan +4 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 1997 A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200.
K.M. Carvalho +3 more
doaj +1 more source
Local renin angiotensin system and sperm DNA fragmentation
Asian Journal of Andrology, 2022 The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto +6 more
doaj +1 more source
Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo [PDF]
, 2008 Endothelial barrier dysfunction is a hallmark of many severe pathologies, including sepsis or atherosclerosis. The cardiovascular hormone atrial natriuretic peptide (ANP) has increasingly been suggested to counteract endothelial leakage.
Bihari, Peter +9 more
core +1 more source
The role of endothelin-1 in pulmonary arterial hypertension. [PDF]
, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core +1 more source
Amyloid/Melanin distinctive mark in invertebrate immunity [PDF]
Invertebrate Survival Journal, 2012 Protostomes and Deuterostomes show the same nexus between melanin production, and amyloid fibril production, i.e., the presence of melanin is indissolubly linked to amyloid scaffold that, in turn, is conditioned by the redox status/cytoplasmic pH ...
A Grimaldi +7 more
doaj +1 more source
Lokalisation und Gen - Expressionsregulation der neutralen Endopeptidase in der humanen Prostata [PDF]
, 2004 Die neutrale Endopeptidase (NEP, EC 3.4.24.11; weitere Synonyme: Neprilysin, CD 10, CALLA) ist ein Typ II - integrales Membranenzym in Säugerzellen, die als Zink enthaltende Endopeptidase die lokale Konzentrationen der Peptidsubstrate und
Prof. Dr. G. Aumüller, Song, Jian
core +1 more source
Sex differences in the aging pattern of renin–angiotensin system serum peptidases [PDF]
, 2017 Background: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system ...
Echevarría Orella, Enrique +7 more
core +5 more sources
Patologìâ, 2019 The average prevalence of сhronic heart failure in the adult population, according to the statistics of different countries, ranges from 1.5 % to 5.5 % and therefore the study of this problem and of finding new approaches to the treatment of сhronic ...
T. V. Ashcheulova +2 more
doaj +1 more source
CURRENT TARGET OF ANTIHYPERTENSIVE THERAPY. DATA FROM CLINICAL TRIALS. PART 1
Рациональная фармакотерапия в кардиологии, 2015 Arterial hypertension (HT) takes leading position in the structure of morbidity and mortality among the cardiovascular diseases in the economically developed and developing countries of the world.
V. V. Popov, N. A. Bulanov, G. G. Ivanov
doaj +3 more sources