Results 11 to 20 of about 49,790 (212)

Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases [PDF]

Frontiers in Physiology, 2018
Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-
Carlos P. Vio, Carlos P. Vio, Daniela Salas, Carlos Cespedes, Jessica Diaz-Elizondo, Natalia Mendez, Natalia Mendez, Julio Alcayaga, Rodrigo Iturriaga   +8 more
doaj   +2 more sources

Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough [PDF]

BMC Complementary Medicine and Therapies, 2020
Background In recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum.
Weigang Jia, Wei Wang, Rui Li, Quanyu Zhou, Ying Qu, Yumei Jia, Zhiheng Zhang, Chengwei Wan, Wanwan Zhang   +8 more
doaj   +2 more sources

The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts. [PDF]

PLoS ONE, 2016
We recently reported that the over-expression of skin fibroblast-derived neutral endopeptidase (NEP) plays a pivotal role in impairing the three-dimensional architecture of dermal elastic fibers during the biological mechanism of ultraviolet (UV)-induced
Hiroaki Nakajima, Shuko Terazawa, Takao Niwano, Yorihiro Yamamoto, Genji Imokawa   +4 more
doaj   +2 more sources

Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase [PDF]

BMC Cancer, 2022
Background We have previously reported that a new intronless gene for casein kinase 2α (CK2α), CSNK2A3, is expressed in human cells. The promoter of the well-known CK2α, CSNK2A1, displays characteristics of a housekeeping gene, whereas CSNK2A3 has a ...
Adhikarimayum Lakhikumar Sharma, Puyam Milan Meitei, Takhellambam Chanu Machathoibi, Naorem Tarundas Singh, Thiyam Ramsing Singh, Lisam Shanjukumar Singh   +5 more
doaj   +2 more sources

In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study [PDF]

EJNMMI Research
Background A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation.
Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A. Hans Vija, Roger Schibli, Susanne Geistlich, Martin Behe, Emanuel R. Christ, Damian Wild   +13 more
doaj   +2 more sources

Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure [PDF]

European Journal of Medical Research, 2011
Secondary activation of the endothelin system is thought to be involved in toxic liver injury. This study tested the hypothesis that dual endothelin-converting enzyme / neutral endopeptidase blockade might be able to attenuate acute toxic liver injury ...
Hocher B, Heiden S, von Websky K, Rahnenführer J, Kalk P, Pfab T   +5 more
doaj   +2 more sources

Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice [PDF]

Journal of Obesity, 2012
We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) activity.
Lawrence Coppey, Bao Lu, Craig Gerard, Mark A. Yorek   +3 more
doaj   +2 more sources

Neutral endopeptidase modulation of septic shock. [PDF]

The Journal of experimental medicine, 1995
Neutral endopeptidase (NEP; EC. 3.4.24.11) is a type 2 cell surface metalloprotease known by a variety of eponyms, including enkephalinase, common acute lymphoblastic leukemia antigen, and CD10. Identified substrates are largely neural or humoral oligopeptide agonists, and the enzyme functions to terminate signaling by degrading the ligand, analogously
B, Lu, N P, Gerard, L F, Kolakowski, M, Bozza, D, Zurakowski, O, Finco, M C, Carroll, C, Gerard   +7 more
openaire   +4 more sources

Divergent Selection on Dispersal Targets Chemosensory and Neuronal Genes in Tribolium castaneum [PDF]

Molecular Ecology, Volume 35, Issue 8, April 2026.
ABSTRACT Dispersal is key to the life history, ecology and evolution of many organisms and important in pest invasiveness. However, the genetic architecture underlying variation in dispersal behaviour remains poorly understood outside of a few model species.
Michael D. Pointer, Will J. Nash, Lewis G. Spurgin, Mark McMullan, Simon Butler, David S. Richardson   +5 more
wiley   +2 more sources

Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy [PDF]

Prostate Cancer, 2012
Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods.
Panagiotis J. Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, George Moutzouris, Anna Patrikidou, Ioannis A. Voutsadakis, Danai D. Daliani, Elias Zintzaras, Michael D. Melekos, Christos N. Papandreou   +9 more
doaj   +2 more sources