Results 1 to 10 of about 10,858 (158)
Clinical relevance of Neutral Endopeptidase (NEP/CD10) in melanoma [PDF]
Journal of Translational Medicine, 2007 Background Overexpression of Neutral Endopeptidase (NEP) has been reported in metastatic carcinomas, implicating NEP in tumor progression and suggesting a role for NEP inhibitors in its treatment.
Zhou Xi +16 more
doaj +2 more sources
Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
M.A.S. Medeiros +4 more
doaj +5 more sources
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury [PDF]
Respiratory Research, 2010 Background Neutral endopeptidase (NEP), an enzyme that cleaves inflammatory bioactive peptides, may play a protective role in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).
Kiuchi Kazutoshi +4 more
doaj +2 more sources
Serum neprilysin levels are elevated in preeclampsia
Taiwanese Journal of Obstetrics & Gynecology, 2021 Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive ...
Nevin Tüten +8 more
doaj +1 more source
Metabolism of renin-angiotensin and enkephalin in human follicular fluid: An experimental study
International Journal of Reproductive BioMedicine, 2022 Background: The relationship between the biochemical characteristics of follicular fluid (FF), oocyte quality and embryonic development has not yet been elucidated.
Maria Victoria Rodríguez Gallego +5 more
doaj +1 more source
Neutral endopeptidase expression in mesangial cells [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2003 In the kidney, neutral endopeptidase (NEP) is implicated in the metabolism of several peptides involved in blood pressure and sodium homeostasis control, such as the atrial natriuretic peptide, bradykinin and angiotensin I. Due to its physiological importance in the modulation of pressor responses, the presence of NEP in mouse mesangial cells has been
Fabiana, Ebihara +3 more
openaire +5 more sources
Clinical and Translational Allergy, 2021 Background Substance P (SP) and toll‐like receptors (TLRs) contribute to airway disease, particularly during viral infection. We recently demonstrated that SP can act as an initial response to viral stimuli in the upper airway by upregulating TLRs in the
Olivia Larsson +4 more
doaj +1 more source
Molecules, 2022 Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase ...
Magdalena Mizerska-Kowalska +4 more
doaj +1 more source
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase. [PDF]
PLoS ONE, 2009 BackgroundNeutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation.
Thomas Walther +13 more
doaj +1 more source
Frontiers in Pharmacology, 2012 Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin +2 more
doaj +1 more source