Results 61 to 70 of about 38,595 (171)

A liver metalloendopeptidase which degrades the circulating hypotensive peptide hormones bradykinin and atrial natriuretic peptide

Brazilian Journal of Medical and Biological Research, 1999
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human liver using successive steps of chromatography on DEAE-cellulose, hydroxyapatite and Sephacryl S-200.
Carvalho K.M., Nava R.A., França M.S.F., Medeiros M.A.S., Camarão G.C., Juliano L.   +5 more
doaj  

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Toward the Bioremediation of Nylon Waste Materials: Genome Mining Leads to the Identification of a Thermostable Laurolactamase From Thermopolyspora flexuosa

ChemSusChem, Volume 19, Issue 1, January 2026.
To enhance nylon waste remediation, genome mining was used to identify a thermostable laurolactam hydrolase from Thermopolyspora flexuosa with activity against an important cyclic nylon derivative. Substrate scope analysis and structural modeling revealed key features controlling enzyme‐substrate compatibility, providing a promising foundation for ...
Maria E. Cleveland, Amir R. Bunyat‐zada, Esther R. Hoffman, Graeme W. Howe   +3 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Idiopathic membranous nephropathy: Evolution in understanding the problem [PDF]

Терапевтический архив, 2016
The review highlights the evolution of ideas on the mechanisms responsible for the development of membranous nephropathy (MN), glomerulopathy that is the most common cause of nephrotic syndrome in adults. Primary emphasis is placed on the primary form of
I N Bobkova, P A Kakhsurueva, E V Stavrovskaya   +2 more
doaj  

Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due to injury and is a significant factor in conditions such as PH.
Yuefu Zhao, Jinyu Wang, Yujie Qiao, Xiangyun Gai, Jiacheng Hu, Hongmai Wang, Qingqing Xia, Qiuqin Hu, Zhanqiang Li, Cen Li, Hongtao Bi   +10 more
wiley   +1 more source

A Missing Link Between a High Salt Intake and Blood Pressure Increase

Journal of Pharmacological Sciences, 2006
.: It is widely accepted that a high sodium intake triggers blood pressure rise. However, only one-third of the normotensive subjects were reported to show salt-sensitivity in their blood pressure.
Makoto Katori, Masataka Majima
doaj   +1 more source

Bronchial responses to substance P after antigen challenge in the guinea-pig: in vivo and in vitro studies

Mediators of Inflammation, 1992
The effect of antigen challenge on the airway responses to substance P and on the epithelial neutral endopeptidase (NEP) activity was investigated in aerosol sensitized guinea-pigs.
E. Boichot, V. Lagente, G. Le Gall, C. Carré, J. M. Mencia-Huerta, P. Braquet, A. Lockhart, N. Frossard   +7 more
doaj   +1 more source

Research progress on the pathogenesis of primary membranous nephropathy

Guangxi Yike Daxue xuebao
This article reviews the pathogenesis of primary membranous nephropathy (PMN) in recent years, encompassing the latest findings of genetic, antigenic, environmental factors, and intestinal flora, etc., so as to provide a reference for further ...
LIU Jianing, ZHU Junjie, LIU Yun, CEN Tao, ZHANG Li'e, NONG Qingqing   +5 more
doaj   +1 more source

Novel targets for immunotherapy in glomerulonephritis

Biologics: Targets & Therapy, 2008
Mary H FosterDepartment of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USAAbstract: Glomerulonephritis is a common cause of chronic kidney disease and end stage renal ...
Mary H Foster
doaj