Results 91 to 100 of about 441,679 (347)

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Nature, 2021
D. Planas, Nell Saunders, P. Maes, F. Guivel-Benhassine, C. Planchais, Julian Buchrieser, William Bolland, F. Porrot, I. Staropoli, F. Lemoine, H. Péré, D. Veyer, J. Puech, Julien Rodary, G. Baele, S. Dellicour, J. Raymenants, Sarah Gorissen, Caspar Geenen, B. Vanmechelen, T. Wawina-Bokalanga, Joan Martí-Carreras, L. Cuypers, A. Sève, L. Hocqueloux, T. Prazuck, F. Rey, E. Simon-Lorière, T. Bruel, H. Mouquet, E. André, O. Schwartz   +31 more
semanticscholar   +1 more source

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

bioRxiv, 2020
Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of most COVID-19 vaccines and being developed as therapeutics, escape mutations could compromise such countermeasures. To define the immune-mediated mutational landscape
Zhuoming Liu, L. VanBlargan, Paul W. Rothlauf, L. Bloyet, Rita E. Chen, S. Stumpf, Haiyan Zhao, J. Errico, E. Theel, A. Ellebedy, D. Fremont, M. Diamond, S. Whelan   +12 more
semanticscholar   +1 more source

Temporal Variation in Bacterial Community Characteristics Shaped by Habitat in a Reservoir Buffer Strip in China

Ecology and Evolution
Habitat and temporal variation can both influence microbial community dynamics, although their relative importance in reservoir buffer zones with complex hydrology regimes and dramatically altered environments remains controversial. To elucidate this, we
Tengfei Yan, Zhengxin Wang, Zhen Wang, Yong Qin, Zheng Wang, Songwei Li   +5 more
doaj   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Evaluation of SARS‐CoV‐2 neutralizing antibodies using a CPE‐based colorimetric live virus micro‐neutralization assay in human serum samples

Journal of Medical Virology, 2020
The micro‐neutralization assay is a fundamental test in virology, immunology, vaccine assessment, and epidemiology studies. Since the SARS‐CoV‐2 outbreak at the end of December 2019 in China, it has become extremely important to have well‐established and
A. Manenti, Marta Maggetti, Elisa Casa, Donata Martinuzzi, Alessandro Torelli, C. Trombetta, S. Marchi, E. Montomoli   +7 more
semanticscholar   +1 more source

Structural insights into the dynamic and controlled multiphase evolution of layered-spinel heterostructured sodium oxide cathode

Cell Reports Physical Science, 2021
Summary: Concepts in sodium oxide cathode composite structures have captured widespread attention; however, the detailed monitoring and accurate control of composite structural evolution during charge and discharge process remain challenging, especially ...
Yao Xiao, Yan-Fang Zhu, Lin Li, Peng-Fei Wang, Wei Zhang, Chao Li, Shi-Xue Dou, Shu-Lei Chou   +7 more
doaj  

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Comparison of Four SARS-CoV-2 Neutralization Assays

Vaccines, 2020
Neutralizing antibodies are a major correlate of protection for many viruses including the novel coronavirus SARS-CoV-2. Thus, vaccine candidates should potently induce neutralizing antibodies to render effective protection from infection.
L. Riepler, A. Rössler, Albert Falch, A. Volland, W. Borena, D. von Laer, J. Kimpel   +6 more
semanticscholar   +1 more source

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

Advanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann, Eduard Ortlieb, Hendrik Wester, Paul Christoph Gembarski, Bernd‐Arno Behrens, Roland Lachmayer   +5 more
wiley   +1 more source