Results 91 to 100 of about 454,570 (346)

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Nature, 2021
D. Planas, Nell Saunders, P. Maes, F. Guivel-Benhassine, C. Planchais, Julian Buchrieser, William Bolland, F. Porrot, I. Staropoli, F. Lemoine, H. Péré, D. Veyer, J. Puech, Julien Rodary, G. Baele, S. Dellicour, J. Raymenants, Sarah Gorissen, C. Geenen, B. Vanmechelen, T. Wawina-Bokalanga, Joan Martí-Carreras, L. Cuypers, A. Sève, L. Hocqueloux, T. Prazuck, F. Rey, E. Simon-Lorière, T. Bruel, H. Mouquet, E. André, O. Schwartz   +31 more
semanticscholar   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

Emerging Microbes and Infections, 2020
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease.
Pengfei Wang, Lihong Liu, Manoj S. Nair, Michael T. Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J. Purpura, Justin C. Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, David D. Ho   +17 more
doaj   +1 more source

A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies [PDF]

, 2022
Santhik Subhasingh Lupitha, Pramod Darvin, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Soumya Jaya Divakaran, Easwaran Sreekumar, Shijulal Nelson‐Sathi, Perunthottathu K. Umasankar, Sara R. Jones, Iype Joseph, Madhavan Radhakrishna Pillai, T.R. Santhoshkumar   +11 more
openalex   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Evaluation of hot dry rock reservoir stimulation based on microseismic monitoring method: a case study of the Northern Jiangsu Basin

Frontiers in Earth Science
The reservoir stimulation is an indispensable part in the development of hot dry rock, and the evaluation of reservoir stimulation is particularly crucial for guiding the subsequent implementation of Enhanced Geothermal Systems (EGS). This paper proposes
Wenhao Xu, Xinglong Xie, Shanxin Yi, Shanxin Yi, Xianpeng Jin, Junpeng Guan, Junpeng Guan, Jun Chen, Jun Chen, Yongbiao Yang, Yongbiao Yang   +10 more
doaj   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster

Nature Medicine, 2022
Chaitanya Kurhade, Jing Zou, Hongjie Xia, Mingru Liu, Hope C. Chang, P. Ren, Xuping Xie, P. Shi   +7 more
semanticscholar   +1 more source

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source