Results 91 to 100 of about 655,602 (382)

A Cross-Reactive Mouse Monoclonal Antibody against Rhinovirus Mediates Phagocytosis In Vitro

Proceedings, 2020
Human rhinoviruses (RVs) are the main cause of the common cold worldwide. To date, more than 160 serotypes of the virus have been recognized. These viruses are categorized into three major groups: A, B, and C.
Mohammad Amin Behzadi, James Duehr, Angela Choi, Michael Schotsaert, Adolfo García-Sastre, Peter Palese, Raffael Nachbagauer   +6 more
doaj   +1 more source

Neutrality

, 2014
During the 19th century, neutrality evolved into a set of legal and political tools designed to limit the impact of wars on the international system. This form of neutrality did not survive the first “total war”; remaining neutral was still possible, but only in closely circumscribed conditions.
openaire   +5 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Neutralization with Simultaneous Separation of Metallic Ions from Condensed Water Through Capillary Polypropylene and Cellulose Derivatives

Proceedings, 2020
An interesting and unpredictable environmental issue raises condensing plants. [...]
Anca -Maria Cimbru, Aurelia Cristina Nechifor, Paul Constantin Albu, Gheorghe Nechifor   +3 more
doaj   +1 more source

SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

Frontiers in Immunology, 2022
IntroductionThe ongoing COVID-19 pandemic situation caused by SARS-CoV-2 and variants of concern such as B.1.617.2 (Delta) and recently, B.1.1.529 (Omicron) is posing multiple challenges to humanity.
Anja Schlör, Stefan Hirschberg, Ghada Ben Amor, Toni Luise Meister, Prerna Arora, Stefan Pöhlmann, Stefan Pöhlmann, Markus Hoffmann, Stephanie Pfaender, Omar Kamal Eddin, Julian Kamhieh-Milz, Julian Kamhieh-Milz, Katja Hanack, Katja Hanack   +13 more
doaj   +1 more source

Cellular Nanosponges for Biological Neutralization

Advances in Materials, 2021
Biological neutralization represents a general strategy that deploys therapeutic agents to bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent them from causing the diseases.
Shuyan Wang, Dan Wang, Yaou Duan, Zhidong Zhou, Weiwei Gao, Liangfang Zhang   +5 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

Emerging Microbes and Infections, 2020
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease.
Pengfei Wang, Lihong Liu, Manoj S. Nair, Michael T. Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J. Purpura, Justin C. Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, David D. Ho   +17 more
doaj   +1 more source

A simple protein-based surrogate neutralization assay for SARS-CoV-2

bioRxiv, 2020
Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcomes ...
K. Abe, Zhijie Li, R. Samson, Payman Samavarchi-Tehrani, Emelissa J. Valcourt, H. Wood, P. Budylowski, A. Dupuis, Roxie C. Girardin, B. Rathod, Jenny H. Wang, M. Barrios-Rodiles, K. Colwill, A. McGeer, S. Mubareka, J. Gommerman, Y. Durocher, M. Ostrowski, K. McDonough, M. Drebot, S. Drews, J. Rini, A. Gingras   +22 more
semanticscholar   +1 more source