Results 101 to 110 of about 655,602 (382)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Reactions of C+ + Cl-, Br-, and I--A comparison of theory and experiment. [PDF]

, 2019
Rate constants for the reactions of C+ + Cl-, Br-, and I- were measured at 300 K using the variable electron and neutral density electron attachment mass spectrometry technique in a flowing afterglow Langmuir probe apparatus. Upper bounds of <10-8 cm3
Engeling, Kenneth W, Hedvall, Patrik, Larson, Åsa, Miller, Thomas M, Orel, Ann E, Sawyer, Jordan C, Shuman, Nicholas S, Viggiano, Albert A   +7 more
core   +2 more sources

Structural basis for broad coronavirus neutralization

Nature Structural & Molecular Biology, 2020
Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the possibility of identifying antibodies with broad neutralizing activity, we isolated a ...
M. M. Sauer, M. Tortorici, Young-Jun Park, A. Walls, Leah J. Homad, O. Acton, John E. Bowen, Chunyan Wang, X. Xiong, Willem de van der Schueren, J. Quispe, B. Hoffstrom, B. Bosch, A. McGuire, D. Veesler   +14 more
semanticscholar   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats [PDF]

, 2015
Background: Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and ...
Berndtsson, Louise Treiberg, Hosie, Margaret, Lindhe, Anna, Samman, Ayman, Thibault, Jean-Christophe, Wensman, Jonas Johansson   +5 more
core   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Evaluation of hot dry rock reservoir stimulation based on microseismic monitoring method: a case study of the Northern Jiangsu Basin

Frontiers in Earth Science
The reservoir stimulation is an indispensable part in the development of hot dry rock, and the evaluation of reservoir stimulation is particularly crucial for guiding the subsequent implementation of Enhanced Geothermal Systems (EGS). This paper proposes
Wenhao Xu, Xinglong Xie, Shanxin Yi, Shanxin Yi, Xianpeng Jin, Junpeng Guan, Junpeng Guan, Jun Chen, Jun Chen, Yongbiao Yang, Yongbiao Yang   +10 more
doaj   +1 more source

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Nature, 2021
D. Planas, D. Veyer, A. Baidaliuk, I. Staropoli, F. Guivel-Benhassine, M. M. Rajah, C. Planchais, F. Porrot, Nicolas Robillard, J. Puech, M. Prot, F. Gallais, P. Gantner, A. Velay, J. Le Guen, N. Kassis-Chikhani, Dhiaeddine Edriss, L. Bélec, A. Sève, L. Courtellemont, H. Péré, L. Hocqueloux, S. Fafi-Kremer, T. Prazuck, H. Mouquet, T. Bruel, E. Simon-Lorière, F. Rey, O. Schwartz   +28 more
semanticscholar   +1 more source

NEUTRALITY AND PLEASURE

Economics and Philosophy, 2007
John Broome's ground-breaking Weighing Lives makes precise, and supplies arguments previously lacking for, several views which for centuries have been central to the utilitarian tradition. In gratitude for his enlightening arguments, I shall repay him in this paper by showing how he could make things easier for himself by denying neutrality and ...
openaire   +2 more sources