Results 111 to 120 of about 655,602 (382)

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Nature, 2021
D. Planas, Nell Saunders, P. Maes, F. Guivel-Benhassine, C. Planchais, Julian Buchrieser, William Bolland, F. Porrot, I. Staropoli, F. Lemoine, H. Péré, D. Veyer, J. Puech, Julien Rodary, G. Baele, S. Dellicour, J. Raymenants, Sarah Gorissen, C. Geenen, B. Vanmechelen, T. Wawina-Bokalanga, Joan Martí-Carreras, L. Cuypers, A. Sève, L. Hocqueloux, T. Prazuck, F. Rey, E. Simon-Lorière, T. Bruel, H. Mouquet, E. André, O. Schwartz   +31 more
semanticscholar   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Temporal Variation in Bacterial Community Characteristics Shaped by Habitat in a Reservoir Buffer Strip in China

Ecology and Evolution
Habitat and temporal variation can both influence microbial community dynamics, although their relative importance in reservoir buffer zones with complex hydrology regimes and dramatically altered environments remains controversial. To elucidate this, we
Tengfei Yan, Zhengxin Wang, Zhen Wang, Yong Qin, Zheng Wang, Songwei Li   +5 more
doaj   +1 more source

Evaluation of the impact of climate change on the ecological resistance and ecological corridors based on set pair analysis theory

Ecological Indicators
Climate change significantly impacts ecological resistance and ecological corridors. However, the difficulty in evaluating this impact lies in two crucial issues: (i) the uncertainty arising from spatial heterogeneity, and (ii) the diversity of impacts ...
Yan Feng, Luo Ping, Wu Hongliang, Yao Jianglin   +3 more
doaj   +1 more source

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge [PDF]

, 2016
End-stage liver disease caused by hepatitis C virus (HCV) infection is a major indication for liver transplantation. However, immediately after transplantation the liver graft of viremic patients universally becomes infected by circulating virus ...
Baumert, Thomas F., Cole, Sarah, Desombere, Isabelle, Fafi-Kremer, Samira, Farhoudi, Ali, Heydmann, Laura, Leroux-Roels, Geert, McKeating, Jane A., Meuleman, Philip, Patel, Arvind H., Pessaux, Patrick, Van Houtte, Freya, Verhoye, Lieven   +12 more
core   +2 more sources

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

bioRxiv, 2020
Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of most COVID-19 vaccines and being developed as therapeutics, escape mutations could compromise such countermeasures. To define the immune-mediated mutational landscape
Zhuoming Liu, L. VanBlargan, Paul W. Rothlauf, L. Bloyet, Rita E. Chen, S. Stumpf, Haiyan Zhao, J. Errico, E. Theel, A. Ellebedy, D. Fremont, M. Diamond, S. Whelan   +12 more
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Design of Multi-Antenna System for UMTS Clamshell Mobile Phones with Ground Plane Effects Considerations [PDF]

, 2014
In this paper, the influence of the ground plane dimensions on the port-to-port isolation of two closely-spaced Universal Mobile Telecommunications System (UMTS) Planar Inverted-F Antennas (PIFAs) with and without neutralization line is first presented ...
Addaci, R., Diallo, A., Le Thuc, P., Luxey, C., Staraj, R.   +4 more
core   +2 more sources

Evidence for two-electron processes in the mutual neutralization of O- with O+ and N+ at Subthermal Collision Energies

, 2018
We have measured total absolute cross sections for the Mutual Neutralization (MN) of O- with O+/N+. A fine resolution (of about 50 meV) in the kinetic energy spectra of the product neutral atoms allows unique identification of the atomic states ...
Cederquist, H., de Ruette, N., Dochain, A., Kaminska, M., Launoy, T., Nascimento, R. F., Schmidt, H. T., Stockett, M. H., Urbain, X., Vaeck, N.   +9 more
core   +1 more source