Results 41 to 50 of about 4,873,920 (320)

TOXIN-ANTITOXIN REACTION WITHOUT NEUTRALIZATION [PDF]

Journal of Experimental Medicine, 1932
1. Collodion particles adsorb diphtheria or tetanus or botulinus toxins. These toxins are retained on the particles when washed but are at least in part released in the animal. 2. The adsorbed toxins are neutralized by adsorption of the corresponding antitoxins but are unaffected by other serums. 3.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An Eco-Friendly Neutralization Process by Carbon Mineralization for Ca-Rich Alkaline Wastewater Generated from Concrete Sludge

Metals, 2017
Waste-concrete recycling processes using wet-based crushing methods inevitably generate a large amount of alkaline concrete sludge, as well as wastewater, which contains abundant Ca ions. The Ca-rich alkaline wastewater must then be neutralized for reuse
Jongchan Yoo, Heeyoung Shin, Sangwoo Ji
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Assessment of the ability of SARS-CoV-2 strains of genetic variants B.1.1 and JN.1 to evade neutralizing antibodies from 2020 and 2023 convalescent patients

Инфекция и иммунитет
Introduction. The SARS-CoV-2 virus is a highly variable pathogen accounted for by random mutations leading to the emergence of new genetic variants. Natural selection of SARS-CoV-2 variants is, among other things, the result of population level immunity ...
Stepan A. Pyankov, A. V. Zaykovskaya, A. V. Rybel, S. A. Bodnev, O. V. Pyankov   +4 more
doaj   +1 more source

Tuning the Supramolecular Structures of Metal-Free Porphyrin via Surfactant Assisted Self-Assembly to Enhance Photocatalytic Performance

Nanomaterials, 2019
Metal-free porphyrin with good planarity is beneficial to π−π stack interactions, which promotes electron coupling and the separation and transfer of photogenerated carriers.
Jinrong Lu, Zihan Li, Weijia An, Li Liu, Wenquan Cui   +4 more
doaj   +1 more source

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite
Yuan Li, Jian Zheng, Zhizhong Pan, Penghui Zhou, Guochen Liu, Wu Jiang, Pei-Rong Ding, Zexian Liu, Qiaoqi Sui, Dingxin Liu, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Qingjian Ou, Binyi Xiao, Yihong Ling, Jiewei Chen, Zhixiang Zuo   +18 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The immune response after vaccination in recipients against different subtypes of tick-borne encephalitis virus (Flaviviridae: Orthoflavivirus)

Вопросы вирусологии
Introduction. There are three antigenic subtypes of tick-borne encephalitis virus (TBEV): the European, Far Eastern and Siberian subtypes. The article discusses the topic of cross-protective neutralizing antibodies against different subtypes of TBEV ...
Ekaterina A. Orlova, Alla L. Ivanova, Vladimir A. Mishchenko, Ivan P. Bykov, Ivan V. Vyalykh, Natalia L. Fadeeva, Veronica V. Patlusova, Mikhail F. Vorovitch, Nadezhda M. Kolyasnikova   +8 more
doaj   +1 more source

Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis [PDF]

, 2016
Background: Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens type A. Due to the rapid progress and fatal outcome of the disease, vaccination would be of high value. In this study, C.
Deprez, Piet, Ducatelle, Richard, Goossens, Evy, Haesebrouck, Freddy, Pardon, Bart, Rodrigo, Diego, Schauvliege, Stijn, Timbermont, Leen, Valgaeren, Bonnie, Van Immerseel, Filip, Verherstraeten, Stefanie   +10 more
core   +2 more sources