Results 41 to 50 of about 95,434 (266)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Process optimization using response surface design for diacylglycerol synthesis from palm fatty acid distillate by enzymatic esterification [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2013 Diacylglycerols (DAG) were synthesized by lipase-catalyzed esterification of glycerol with palm fatty acid distillate(PFAD). Lipase from Rhizomucor miehei was used and the reaction was carried out at 45°C.
Songsri Santisawadi +3 more
doaj
Jurnal Teknik Kimia dan Lingkungan, 2017 Surfactant is a surface active agent which is widely applied in chemical industry related to its ability to stabilize the emulsion between the oil phase and the water phase.
Abdul Chalim +4 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Reactions of neutral interstellar species
Chemical Physics, 2007 Abstract Recent evidence has shown that low temperature neutral–neutral reactions may be more important in the chemistry of the interstellar medium than originally realized. In this paper, possible chemical reactions among known carbon-, hydrogen- and oxygen-bearing interstellar neutral molecules have been explored theoretically using density ...
Department of Chemistry and Center for Chemical Physics, University of Florida, Gainesville, FL 32611-7200, USA ( host institution ) +4 more
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Synthesis and Spectroscopic Characterization of Protic Tris(2-Hydroxyethyl)-Ammonium Ionic Liquids
Journal of the Turkish Chemical Society, Section A: Chemistry, 2020 Protic ionic liquids (PILs) having tris(2-hydroxyethyl)ammonium (or triethanolammonium) as cations and methacrylate, dihydrogenborate, formate, acetate as anions have been synthesized through stoichiometric neutralization reaction.
Hüseyin AKBAŞ
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source