Results 101 to 110 of about 1,846,702 (390)

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]

, 2013
The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
Cane, Patricia, Medley, Graham, Mutunga, M. N., Nokes, D. James, Okiro, Emelda A., Sande, Charles J.   +5 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Potently neutralizing and protective human antibodies against SARS-CoV-2

Nature, 2020
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health1 and the medical countermeasures available so far are limited2,3.
Seth J. Zost, P. Gilchuk, J. Case, E. Binshtein, Rita E. Chen, Joseph P. Nkolola, A. Schäfer, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveen Chandra Suryadevara, David R. Martinez, Lauren E. Williamson, E. Chen, Taylor Jones, Samuel B. Day, Luke Myers, Ahmed O. Hassan, Natasha M. Kafai, Emma S. Winkler, J. Fox, S. Shrihari, Benjamin K. Mueller, J. Meiler, A. Chandrashekar, N. Mercado, J. Steinhardt, K. Ren, Y. Loo, N. Kallewaard, B. McCune, Shamus P. Keeler, M. Holtzman, D. Barouch, Lisa E. Gralinski, R. Baric, Larissa B. Thackray, M. Diamond, R. Carnahan, J. Crowe   +40 more
semanticscholar   +1 more source

Insights into neutralization of animal viruses gained from study of influenza virus [PDF]

, 1991
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Colonno, Dimmock, Eisenlohr, Kennedy-Stoskopf, Kjellen, Kukuhara, Lamb, M. C. Outlaw, Mandel, Mandel, Mandel, McClure, N. J. Dimmock, Svehag, Thomas, Thomas, Viitala, Wharton   +17 more
core   +2 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Correlates of broadly neutralizing antibody development [PDF]

Current Opinion in HIV and AIDS, 2019
Broadly neutralizing antibodies (bnAbs) are considered a key component of an effective HIV-1 vaccine, but despite intensive efforts, induction of bnAbs by vaccination has thus far not been possible. Potent bnAb activity is rare in natural infection and a deeper understanding of factors that promote or limit bnAb evolution is critical to guide bnAb ...
Abela, Irene A, Kadelka, Claus, Trkola, Alexandra   +2 more
openaire   +3 more sources

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, Volume 15, Issue 7, Page 1103-1112, July 2025.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate

medRxiv, 2020
The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans.
A. Addetia, K. H. Crawford, A. Dingens, H. Zhu, Pavitra Roychoudhury, M. Huang, K. Jerome, J. Bloom, A. Greninger   +8 more
semanticscholar   +1 more source

Neutralization of HIV-1 by antibody

Current Opinion in Immunology, 1996
The humoral immune response to HIV-1 has been extensively studied over the past few years and considerable advances have been made in understanding the dynamics and specificity of the neutralizing antibody component during and after seroconversion. Despite this, there is still no clear understanding of the role of neutralizing antibodies in controlling
openaire   +3 more sources

Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies [PDF]

BMC Systems Biology, 2011
Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-mediated signaling such as antibodies to VEGF. However, it is difficult to predict the effects of VEGF-neutralizing agents.
P. I. Imoukhuede, Marianne O. Engel-Stefanini, Stacey D. Finley, Aleksander S. Popel   +3 more
openaire   +3 more sources