Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies [PDF]
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity
Elias, S.C. +118 more
core +1 more source
Two neutralizing human scFv, b1 and h12 were identified initially using ELISA, employing highly purified virus as the coating antigen. The biosensor technique based on imaging ellipsometrywas employed directly to detect two neutralizing monoclonal ...
王战会 +9 more
core +1 more source
An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT(TM) is functionally superior to Freund's adjuvant [PDF]
Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, the ...
Kerrilyn R Diener +22 more
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Neutralizing antibodies in convalescent patients [PDF]
Uhl, LFK, Chauveau, A
openaire +3 more sources
Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses
Includes bibliographical references.One of the greatest challenges for the development of an effective HIV-1 vaccine is the high genetic diversity of this pathogen and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoprotein ...
Essomba, Rene Ghislain
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core
Background The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2
Dan Li +15 more
doaj +1 more source
Broad Neutralizing Antibodies Against SARS-CoV-2: Current Progress and Engineering Strategies
The high-frequency mutation characteristics of SARS-CoV-2 have posed formidable challenges to the development of vaccines and therapeutic agents.
Tianrong Jia +3 more
doaj +1 more source
openaire +2 more sources
The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses [PDF]
In recent years, high pathogenicity avian influenza (HPAI) virus, H5N1, low pathogenicity avian influenza (LPAI) virus, H9N2, and both HPAI and LPAI H7 viruses have proved devastating for the affected economies reliant on poultry industry, and have posed
Ferrara, Francesca +7 more
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