Results 101 to 110 of about 754,642 (308)

SARS-CoV-2 Neutralizing Antibodies 2.0

Viruses
As the SARS-CoV-2 mutates, especially into those variants causing immune escape, COVID-19 continues to wreak havoc [...]
Youchun Wang
doaj   +1 more source

The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein

mBio, 2013
Following natural dengue virus (DENV) infection, humans produce some antibodies that recognize only the serotype of infection (type specific) and others that cross-react with all four serotypes (cross-reactive).
Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe   +13 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies [PDF]

, 2019
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity
Elias, S.C., Higgins, MK, Crabb, B.S., Illingworth, J.J., Galaway, F., Pattinson, D.J., Silk, SE, de Jongh, Willem A., Gilson, Paul R, Alanine, D.G.W., Higgins, Matthew K., Mehmood, S, Long, Carole A, Donnellan, Francesca R, Robinson, Carol V., Jamwal, A, Payne, Ruth O., Dadonaite, B, Robinson, C.V., de Jongh, W.A., Crabb, BS, Abhishek, Jamwal, Draper, SJ, Silk, Sarah E., Galaway, Francis, Silk, S.E., Dadonaite, B., Elias, SC, Jamwal, A., Jamwal, Abhishek, Foquet, L., Higgins, Matthew K, Elias, Sean C., Draper, Simon J, Higgins, M.K., Jin, J, de Jongh, Willem A, Long, CA, Robinson, Carol V, Elias, Sean C, Labbé, G.M., Kumarasingha, R., Kappe, SHI, Marshall, J.M., Robinson, CV, Quinkert, D., Minkah, Nana K., Minkah, Nana K, Kappe, S.H.I., Williams, BG, Pattinson, DJ, Illingworth, JJ, Marshall, Jennifer M., Pulido, David, Kappe, Stefan H I, Miura, K, Long, Carole A., Payne, R.O., Jin, Jing, Gilson, PR, Pattinson, David, Draper, S.J., Long, C.A., Crabb, Brendan S., Kappe, Stefan H.I., Kumarasingha, Rasika, Illingworth, Joseph J, Silk, Sarah E, Minkah, N.K., Illingworth, Joseph J., Pulido, D, Mehmood, Shahid, Douglas, Alexander D., Mehmood, S., Galaway, F, Douglas, A.D., Alanine, Daniel G W, Williams, Barnabas G, Gilson, Paul R., Williams, Barnabas G., Douglas, AD, Wright, G.J., Labbé, GM, Wright, GJ, Payne, RO, Douglas, Alexander D, Marshall, Jennifer M, Diouf, A, Pulido, D., Dadonaite, Bernadeta, Foquet, Lander, Payne, Ruth O, Miura, K., Draper, Simon J., Diouf, A., Miura, Kazutoyo, Williams, B.G., Gilson, P.R., Labbe, Genevieve M., Diouf, Ababacar, Donnellan, Francesca R., Crabb, Brendan S, Jin, J., Donnellan, F.R., Pattinson, David J, Wright, Gavin J, Minkah, NK, Wright, Gavin J., Labbé, Geneviève M, Kumarasingha, R, Marshall, JM, Quinkert, Doris, Alanine, DGW, Donnellan, FR, Alanine, Daniel, Foquet, L, Quinkert, D, de Jongh, WA   +117 more
core   +1 more source

Antibody neutralization of HIV-1

Immunology Today, 1996
Neutralizing antibodies are a major component of host defense against viruses, and appear to be particularly important in limiting the spread of cell-free virus. Results from vaccine trials in animal models suggest that these antibodies may contribute to protection against human immunodeficiency virus (HIV) infection.
Poignard, P, Klasse, P, Sattentau, Q
openaire   +2 more sources

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Antibody and Virus: Binding and Neutralization

Virology, 2000
During infection with an enveloped virus, antibodiesare elicited to envelope proteins. Some of these antibod-ies bind to envelope spikes on the virion, some bind tononvirion forms of the envelope (“viral debris”), and somebind to both. The relative amounts of different antibodytypes elicited varies from virus to virus.
Burton, Dennis R., Williamson, R.Anthony, Parren, Paul W.H.I.   +2 more
openaire   +2 more sources

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

SARS-CoV-2 fusion-peptide-directed antibodies are elicited by natural infection and can mediate broad sarbecovirus neutralization

Cell Reports
Summary: Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the development of antibodies capable of neutralizing
Alex L. Roederer, Chia Jung Li, Eunice Lim, Yi Cao, Larance Ronsard, Daniel Lingwood, David H. Canaday, Stefan Gravenstein, Alejandro B. Balazs   +8 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source