Results 171 to 180 of about 1,883,437 (383)

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

, 2020
David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Bret J. Musser, Yuhwen Soo, Diana Rofail, Joseph Im, Christina J. Perry, Cynthia X. Pan, Romana Hosain, Adnan Mahmood, John D. Davis, K. C. Turner, Andrea T. Hooper, Jennifer D. Hamilton, Alina Baum, Christos A. Kyratsous, Yun‐Ji Kim, Amanda Cook, Wendy Kampman, Anita Kohli, Yessica Sachdeva, Ximena Graber, Bari Kowal, Thomas DiCioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos   +32 more
openalex   +2 more sources

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development [PDF]

, 2020
Delphine C. Malherbe, Constantinos Kurt Wibmer, Molati Nonyane, Jason S. Reed, D. Noah Sather, David A. Spencer, Jason T. Schuman, Biwei Guo, Shilpi Pandey, Harlan Robins, Byung Park, Deborah H. Fuller, Jonah B. Sacha, Penny L. Moore, Ann J. Hessell, Nancy L. Haigwood   +15 more
openalex   +1 more source

Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model

Advanced Healthcare Materials, EarlyView.
This study develops cyclic peptidepolymer conjugate nanotubes with hydrophobic, drug‐rich cores to enhance drug loading and stability, and demonstrates their responsive disassembly, pharmacokinetics, and anti‐tumour efficacy in colorectal cancer models using the anticancer drug SN‐38.
Sophie K. Hill, Min Zeng, Santhosh Kalash Rajendrakumar, Robert Dallmann, Sébastien Perrier   +4 more
wiley   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth [PDF]

, 2018
Daniel J. Sheward, Jinny C. Marais, Valerie Bekker, Ben Murrell, Kemal Eren, Jinal N. Bhiman, Molati Nonyane, Nigel Garrett, Zenda Woodman, Quarraisha Abdool Karim, Salim S. Abdool Karim, Lynn Morris, Penny L. Moore, Carolyn Williamson   +13 more
openalex   +1 more source

Electrochemical Biosensor for Rapid Detection of Acute Rejection in Kidney Transplants

Advanced Healthcare Materials, EarlyView.
A low‐cost, rapid electrochemical immunosensor coated with a novel antifouling nanocomposite enables single‐step, dual‐biomarker profiling directly from unprocessed urine. Application in a clinical study shows accurate discrimination of acute rejection in kidney transplants from other acute kidney injuries via machine learning.
Rohit Gupta, Nikolaos Salaris, Ashish Kalkal, Fernando Yuen Chang, Maryam Javed, Azhar Ali Khan, Priya Mandal, Stavroula Balabani, Reza Motallebzadeh, Manish K. Tiwari   +9 more
wiley   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape [PDF]

, 2021
Fabian Schmidt, Yiska Weisblum, Magdalena Rutkowska, Daniel Poston, Justin DaSilva, Fengwen Zhang, Eva Bednarski, Alice Cho, Dennis Schaefer-Babajew, Christian Gaebler, Marina Caskey, Michel C. Nussenzweig, Théodora Hatziioannou, Paul D. Bieniasz   +13 more
openalex   +1 more source

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Nature, 2021
U. Şahin, A. Muik, I. Vogler, E. Derhovanessian, L. Kranz, M. Vormehr, Jasmin Quandt, Nicole Bidmon, Alexander Ulges, A. Baum, Kristen E. Pascal, D. Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Peter Koch, R. Hilker, D. Becker, Ann-Kathrin Eller, J. Grützner, Manuel Tonigold, Carsten Boesler, Corinna Rosenbaum, L. Heesen, Marie-Cristine Kühnle, A. Poran, Jesse Z. Dong, U. Luxemburger, Alexandra Kemmer-Brück, D. Langer, M. Bexon, S. Bolte, T. Palanché, A. Schultz, S. Baumann, Azita J. Mahiny, G. Boros, J. Reinholz, G. Szabó, K. Karikó, P. Shi, Camila R. Fontes-Garfias, John L. Perez, Mark Cutler, David Cooper, C. Kyratsous, P. Dormitzer, K. Jansen, Ö. Türeci   +48 more
semanticscholar   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source