Results 161 to 170 of about 754,642 (308)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications

Advanced Science, EarlyView.
Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee, SeongCheol Jang, Wangmyung Choi, Jaewon Park, Jaehyun Hur, Hocheon Yoo, Hyun‐Suk Kim   +6 more
wiley   +1 more source

Cross-Reactive Neutralizing Antibodies Between ZIKV and DENV May Exhibit Serotype Specificity. [PDF]

Biotechnol J
Silveira LAD, Saavedra DP, Junqueira IC, Dietz JDC, Oliveira CR, Lopes-Luz L, Chaves LCS, Ribeiro BM.   +7 more
europepmc   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Progress in enterovirus D68-neutralizing antibodies and vaccines. [PDF]

J Virol
Wang L, Shen J.
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

A multiplex serological assay for quantification of arbovirus antibody kinetics and neutralizing antibodies. [PDF]

PLoS Negl Trop Dis
Garcia L, Yman V, Gasasira MF, Donnadieu F, Rosado J, Cappuccio L, Hoinard D, Desprès P, Petres S, Manuguerra JC, Yoon IK, Hunsawong T, Alera MTP, Gurley ES, Vasilakis N, Weaver SC, Rahman Z, Dorigatti I, Drakeley C, Vigan-Womas I, Niang M, Salje H, Vanhomwegen J, White M.   +23 more
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Fc Functions and Anti-HIV Neutralizing Antibodies: A Perspective

Controversy exists around the relative merits of Fc functions in controlling or prevent-ing HIV-1 infection. Proponents point to general correlations of Fc functions with control of HIV, indicating that non-neutralizing antibodies could force immune ...
Kent, Stephen J., Vanderven, Hillary A.
core   +1 more source

Author Correction: Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus. [PDF]

Nat Commun
Qu Y, Tai W, Ma E, Jiang Q, Fan M, Xiao W, Tian C, Liu Y, Liu J, Wang X, Ge J, Cheng G.   +11 more
europepmc   +1 more source