Results 201 to 210 of about 312,346 (337)

Mild COVID-19 elicits early functional plasmablasts and longterm memory B cells while sustaining neutralizing antibody titers

, 2021
Paola Martinez-Murillo, Barbara C. Meyer, Carlos Manzanas, Géraldine Blanchard‐Rohner, Angela Huttner, Isabella Eckerle, Maria Vono, Elodie von Dach, Jean Villard, Arnaud M. Didierlaurent, C.-A. Siegrist, Christiane S. Eberhardt   +11 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Zika virus infection in early pregnancy increases the likelihood of persistent neutralizing antibodies. [PDF]

PLoS Negl Trop Dis
Falcão de Oliveira E, Carvalho AT, Venancio FA, Quilião ME, Gabeira SCO, Leite SHDS, Salú MDS, Lima SMB, Alves NDS, Moura LDC, Schwarcz WD, Azevedo AS, Demarchi LHF, Zardin MCSU, Lichs GGC, Taira DL, Nascimento AID, Fernandes WS, Alves NO, Casaril Arrua AE, Medeiros MJ, Cunha RVD, Vasconcelos Z, Santos-Pinto CDB, Nielsen-Saines K.   +24 more
europepmc   +1 more source

Premature stop codons in the G glycoprotein of human respiratory syncytial viruses resistant to neutralization by monoclonal antibodies [PDF]

, 1991
Paloma Rueda, Teresa Delgado, Agustı́n Portela, José A. Melero, Blanca García‐Barreno   +4 more
openalex   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential. [PDF]

Npj Viruses
Saito T, Miyamoto H, Igarashi M, Nanbo A, Hayashi R, Paroha R, Siman-Tov G, Littlefield K, Mori-Kajihara A, Click C, Furuyama W, Paessler S, Maruyama J, Takada A.   +13 more
europepmc   +1 more source

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

Cara W. Chao, Kaitlin R. Sprouse, Marcos C. Miranda, Nicholas Catanzaro, Miranda L. Hubbard, Amin Addetia, Cameron Stewart, Jack T Brown, Annie Dosey, Adian Valdez, Rashmi Ravichandran, Grace G. Hendricks, Maggie Ahlrichs, Craig L. Dobbins, Alexis Hand, Jackson McGowan, Blake A. Simmons, Catherine Treichel, Isabelle Willoughby, Alexandra C. Walls, Andrew T. McGuire, Elizabeth M. Leaf, Ralph S. Baric, Alexandra Schäfer, David Veesler, Neil P. King   +25 more
openalex   +1 more source

Clade-specific influences of glycans on the interactions between HIV-1 envelope and broadly neutralizing antibodies [PDF]

Mrinal Arandhara, Yogendra Kumar, Narendra M. Dixit, Prabal K. Maiti   +3 more
openalex   +1 more source

Human Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies against BK and JC Polyomaviruses [PDF]

, 2019
John M. Lindner, Vanessa Cornacchione, Atul Sathe, C. Be, Honnappa Srinivas, Elodie Riquet, Xavier-Charles Leber, Andreas Hein, Matthias B. Wrobel, Meike Scharenberg, Thomas Pietzonka, Christian Wiesmann, Johanna R. Abend, Elisabetta Traggiai   +13 more
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source