Results 211 to 220 of about 309,985 (359)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Zika virus infection in early pregnancy increases the likelihood of persistent neutralizing antibodies. [PDF]

PLoS Negl Trop Dis
Falcão de Oliveira E, Carvalho AT, Venancio FA, Quilião ME, Gabeira SCO, Leite SHDS, Salú MDS, Lima SMB, Alves NDS, Moura LDC, Schwarcz WD, Azevedo AS, Demarchi LHF, Zardin MCSU, Lichs GGC, Taira DL, Nascimento AID, Fernandes WS, Alves NO, Casaril Arrua AE, Medeiros MJ, Cunha RVD, Vasconcelos Z, Santos-Pinto CDB, Nielsen-Saines K.   +24 more
europepmc   +1 more source

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

, 2017
Diogo M. Magnani, Cássia Gisele Terrassani Silveira, Brandon C. Rosen, Michael J. Ricciardi, Núria Pedreño-López, Martin J. Gutman, Varian K. Bailey, Helen S. Maxwell, Aline Domingues, Lucas Gonzalez-Nieto, Vivian I. Avelino‐Silva, Mateus C. Trindade, Juliana Silva Nogueira, Consuelo Silva de Oliveira, Alvino Maestri, Alvina Clara Félix, José Eduardo Levi, Maurício Lacerda Nogueira, Maurício A. Martins, José M. Martinez-Navío, Sebastian Fuchs, Stephen S. Whitehead, Dennis R. Burton, Ronald C. Desrosiers, Esper G. Kallás, David I. Watkins   +25 more
openalex   +2 more sources

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Isolation of neutralizing antibodies against SARS-CoV-2 through an epitope-guided negative screening by phage display. [PDF]

J Biomed Res
Lu M, Chen Y, Liu X, Gao F, Gou L, Ye W, Wen J, Guo X, Gao W.   +8 more
europepmc   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action. [PDF]

Nat Commun
Han X, Ji C, Tian S, Wang F, Cao GP, Li D, Duan X, Tong Z, Qi J, Wang Q, Huang Q, Zhan BD, Gao GF, Yan J.   +13 more
europepmc   +1 more source

Understanding the Acceptability of Broadly Neutralizing Antibodies for HIV Prevention Among At-Risk Populations and Feasibility Considerations for Product Introduction in India: Protocol for a Qualitative Study (Preprint)

, 2023
Joyeeta Mukherjee, Shruta Rawat, Saif ul Hadi, Pritha Aggarwal, Venkatesan Chakrapani, Pratyasha Rath, Pallavi Manchi, Aylur K. Srikrishnan, Shelly Malhotra, Margaret Keane, Alok Gangaramany   +10 more
openalex   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential. [PDF]

Npj Viruses
Saito T, Miyamoto H, Igarashi M, Nanbo A, Hayashi R, Paroha R, Siman-Tov G, Littlefield K, Mori-Kajihara A, Click C, Furuyama W, Paessler S, Maruyama J, Takada A.   +13 more
europepmc   +1 more source