Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
The Hemagglutination Inhibition Test for Rubella: A Comparison of Its Sensitivity to That of Neutralization, Complement Fixation and Fluorescent Antibody Tests for Diagnosis of Infection and Determination of Immunity Status [PDF]
, 1967 Edwin H. Lennette +2 more
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Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Neutralizing, Hemagglutination-Inhibiting and Group Complement-Fixing Antibody Responses in Human Adenovirus Infections [PDF]
, 1966 Nathalie J. Schmidt +2 more
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Advanced Science, EarlyView.This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du +13 more
wiley +1 more source
Quantitative Studies on the Neutralization of Pathogenic Agents in Tissues by Circulating Antibodies
, 1939 U. Friedemann, Bernard Zuger
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Production of Neutralizing Antibody by Mice Injected with Actinophage [PDF]
, 1963 S. G. Bradley, Dennis W. Watson
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Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Effect of Sodium Chloride and pH on the Rate of Neutralization of Cypridina Luciferase by Specific Antibody [PDF]
, 1962 Frederick I. Tsuji +2 more
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