Results 211 to 220 of about 312,346 (337)

Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action. [PDF]

Nat Commun
Han X, Ji C, Tian S, Wang F, Cao GP, Li D, Duan X, Tong Z, Qi J, Wang Q, Huang Q, Zhan BD, Gao GF, Yan J.   +13 more
europepmc   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Neutralizing Antibodies vs. Viruses: Interacting Mechanisms and Escape Tactics. [PDF]

Microorganisms
Lu H, Liu Y, Song Y, Chen L, Zhang L, Li R, Nie X, Zhu G, Ding X, Wang L.   +9 more
europepmc   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Screening and identification of human HPV18VLP neutralizing antibodies from women receiving HPV vaccine. [PDF]

Front Immunol
Gu Y, Zhang R, Wang W, Zhou J, Liu B, Zheng Y, Zuo H, Du Y, Wang Y, Hu R, Zuo Q.   +10 more
europepmc   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Maternal Immunization with VP8* mRNA Vaccine Yields Superior Passive Transfer of Rotavirus-Neutralizing Antibodies to Foals. [PDF]

Vaccines (Basel)
Borba KER, Legere RM, Canaday NM, Skrobarczyk JW, Arnold ZWT, Cotton-Betteridge E, Poveda C, Criscitiello MF, Bordin AI, Berghman LR, Pollet JBK, Cohen ND.   +11 more
europepmc   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques. [PDF]

Nat Commun
Walker-Sperling VEK, Nkolola J, Liu J, Aid M, Julg B, Seaman MS, Barouch DH.   +6 more
europepmc   +1 more source

Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9 [PDF]

, 2019
Hans‐Georg Wirsching, Sonali Arora, Huajia Zhang, Frank Szulzewsky, Patrick J. Cimino, Christophe Quéva, A. McGarry Houghton, Joseph C. Glorioso, Michael Weller, Eric C. Holland   +9 more
openalex   +1 more source