Results 241 to 250 of about 1,883,437 (383)

Could anti-ACE2 antibodies alter the results of SARS-CoV-2 Ab neutralization assays?

, 2022
Raquel Tobes, Eduardo Pareja
openalex   +2 more sources

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Neutralizing Antibodies vs. Viruses: Interacting Mechanisms and Escape Tactics. [PDF]

Microorganisms
Lu H, Liu Y, Song Y, Chen L, Zhang L, Li R, Nie X, Zhu G, Ding X, Wang L.   +9 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques. [PDF]

Nat Commun
Walker-Sperling VEK, Nkolola J, Liu J, Aid M, Julg B, Seaman MS, Barouch DH.   +6 more
europepmc   +1 more source

A mimotope from a solid-phase peptide library induces a measles virus-neutralizing and protective antibody response [PDF]

, 1995
Michael Steward, Carolynne Stanley, Obeid E. Obeid   +2 more
openalex   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

A chemiluminescence immunoassay for detecting neutralizing antibodies of foot-and-mouth disease virus serotype A. [PDF]

Appl Microbiol Biotechnol
Sun M, Bao Y, Li K, Zuo Y, Zhang H, Fu Y, Li P, Sun P, Zhao Z, Jiang T, Bai X, Lin M, Lu Z, Cao Y.   +13 more
europepmc   +1 more source

Fragments of the V1/V2 domain of HIV-1 glycoprotein 120 engineered for improved binding to the broadly neutralizing PG9 antibody

, 2016
Javier F. Morales, Bin Yu, Gerardo Perez, Kathryn A. Mesa, David L. Alexander, Phillip W. Berman   +5 more
openalex   +2 more sources

Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus [PDF]

, 2007
Lei Ba, Christopher E. Yi, Linqi Zhang, David D. Ho, Zhiwei Chen   +4 more
openalex   +1 more source