Results 251 to 260 of about 309,985 (359)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus. [PDF]

Viruses
Yang G, Chen PL, Rovito SW, Minari K, Writt HN, DeBeauchamp J, Crumpton JC, Kercher L, DuBois RM, Webby RJ, Russell CJ.   +10 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

A chemiluminescence immunoassay for detecting neutralizing antibodies of foot-and-mouth disease virus serotype A. [PDF]

Appl Microbiol Biotechnol
Sun M, Bao Y, Li K, Zuo Y, Zhang H, Fu Y, Li P, Sun P, Zhao Z, Jiang T, Bai X, Lin M, Lu Z, Cao Y.   +13 more
europepmc   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control. [PDF]

Nat Immunol
Fisher K, Garcia MA, Frattari GS, Naasz C, Zhuo J, Rosás-Umbert M, Dietz LL, Juhl AK, Falling Iversen E, Olesen R, Schleimann MH, Pahus MH, Johansen IS, Henderson M, Carrere L, Roseto I, Gao C, Yu XG, Fray EJ, Aydin B, Lubbeck D, Lai J, Simonetti FR, Danesh A, Miller I, Mendoza P, Niessl J, Gaebler C, Seaman MS, Kaufmann DE, Lehmann C, Gruell H, Klein F, Caskey M, Nussenzweig MC, Tolstrup M, Jones RB, Gunst JD, Siliciano JD, Lichterfeld M, Siliciano RF, Søgaard OS.   +41 more
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques. [PDF]

Cell Rep
Duan H, Nkolola JP, Wang S, Chaudhari J, Teng IT, Lavine C, Parchment DK, Sellers GS, McKee K, O'Dell S, Choe M, Du H, Zhang B, Perez AAE, Rossler A, Lasrado N, Biju A, Becker JE, Carroll R, Carson AS, Henry AR, Morano NC, Mughal M, Rawi R, Roark RS, Schramm CA, Shen CH, Smith SC, Stephens T, Tsybovsky Y, Van Wazer DJ, Wang H, Yang Y, Rutten L, Langedijk JPM, Cheng C, Wang L, Douek DC, Koup RA, Mascola JR, Shapiro L, Zhou T, Doria-Rose NA, Korber B, Seaman MS, Pierson TC, Kwong PD, Barouch DH.   +47 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Pro-inflammatory cytokine profiles and neutralizing antibodies in JYNNEOS-vaccinated and mpox-diagnosed individuals. [PDF]

NPJ Vaccines
Maciel MSC, de Souza Andrade A, Neri de Oliveira AL, Arias NEC, de Carvalho SH, Xavier MAP, Kroon EG, Campos MA.   +7 more
europepmc   +1 more source