Results 271 to 280 of about 1,883,437 (383)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Seroprevalence of Neutralizing Antibodies in Healthy Adults, in Mexico, Against Human and Simian Adenovirus Types. [PDF]

Viruses
López RE, Valdés Alemán M, Torres-Flores JM, Pérez-Llano Y, Cabrera Gaytán DA, Santacruz Tinoco CE, Alvarado Yaah JE, Anguiano Hernández YM, Martínez Miguel B, Muñoz Medina JE, Sandoval Gutiérrez N, Lagunes IR, Arroyo Pérez JA, González RA.   +13 more
europepmc   +1 more source

Mechanisms of Neutralization of a Human Anti-α-toxin Antibody

, 2014
Vaheh Oganesyan, Li Peng, Melissa Damschroder, Cheng Li, Agnieszka Sadowska, Christine Tkaczyk, Bret R. Sellman, Herren Wu, William F. Dall’Acqua   +8 more
openalex   +1 more source

Author response for "Mechanically driven counter‐regulation of cortical bone formation in response to sclerostin‐neutralizing antibodies"

, 2020
Maude Gerbaix, Patrick Amman, Serge Ferrari   +2 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

An Anti-IL-13 Vaccine Reduces Atopic Dermatitis in Humanized Mice and Induces Neutralizing Antibodies in Nonhuman Primates. [PDF]

Allergy
Mougel A, Lemdani K, Serhan N, Hateb C, Bonnefoy J, Hamdi S, Worrall WPM, Kamphuis JBJ, Andrieux L, Colaone F, Vieira R, Zahm M, Chaubet A, Lachambre S, Ekren R, Leveque E, Guilleminault L, Gaudenzio N, Drouet B, Serra V, Reber LL.   +20 more
europepmc   +1 more source

Rational Design of Vaccines to Elicit Broadly Neutralizing Antibodies to HIV-1 [PDF]

, 2011
Peter D. Kwong, John R. Mascola, Gary J. Nabel   +2 more
openalex   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Potent Cross-neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein. [PDF]

Adv Sci (Weinh)
Ren Y, Fan P, Zhang X, Fang T, Chen Z, Yao Y, Chi X, Zhang G, Zhao X, Sun B, Li F, Liu Z, Song Z, Zhang B, Peng C, Li E, Yang Y, Li J, Chiu S, Yu C.   +19 more
europepmc   +1 more source

A Tripartite Fusion, FaeG-FedF-LT₁₉₂A2:B, of Enterotoxigenic Escherichia coli (ETEC) Elicits Antibodies That Neutralize Cholera Toxin, Inhibit Adherence of K88 (F4) and F18 Fimbriae, and Protect Pigs against K88ac/Heat-Labile Toxin Infection

, 2011
Xiaosai Ruan, Mei Liu, Thomas A. Casey, Weiping Zhang   +3 more
openalex   +1 more source