Results 51 to 60 of about 1,846,702 (390)

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding [PDF]

, 2011
Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective.
Abadir, Alexander, Bjorkman, Pamela J., Boulad, Farid, Burton, Dennis R., Chait, Brian T., Diskin, Ron, Fenyo, David, Ho, David D., Hurley, Arlene, Klein, Florian, Mouquet, Hugo, Myung, Sunnie, Nussenzweig, Michel C., Oliveira, Thiago Y. K., Pereyra, Florencia, Pietzsch, John, Poignard, Pascal, Scheid, Johannes F., Seaman, Michael S., Ueberheide, Beatrix, Velinzon, Klara, Walker, Bruce D.   +21 more
core   +2 more sources

COVID-19 neutralizing antibodies predict disease severity and survival

medRxiv, 2020
COVID-19 exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood.
W. García-Beltrán, E. Lam, M. Astudillo, Diane Yang, T. Miller, J. Feldman, B. Hauser, T. Caradonna, K. Clayton, Adam D Nitido, M. Murali, G. Alter, R. Charles, A. Dighe, J. Branda, J. Lennerz, D. Lingwood, A. Schmidt, A. Iafrate, A. Balazs   +19 more
semanticscholar   +2 more sources

Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

Frontiers in Microbiology, 2023
COVID-19 pandemic is a global public health emergency. Despite extensive research, there are still few effective treatment options available today. Neutralizing-antibody-based treatments offer a broad range of applications, including the prevention and ...
Mingtao Liu, Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun   +11 more
doaj   +1 more source

SARS-CoV-2-Neutralizing Antibodies. [PDF]

Vaccines (Basel)
The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has profoundly and permanently affected many aspects of the world [...]
Liu Y, Nie J.
europepmc   +4 more sources

Antibody and Virus: Binding and Neutralization

Virology, 2000
During infection with an enveloped virus, antibodiesare elicited to envelope proteins. Some of these antibod-ies bind to envelope spikes on the virion, some bind tononvirion forms of the envelope (“viral debris”), and somebind to both. The relative amounts of different antibodytypes elicited varies from virus to virus.
Paul W. H. I. Parren, R. Anthony Williamson, Dennis R. Burton   +2 more
openaire   +2 more sources

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

PLoS ONE, 2019
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple
Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss   +11 more
doaj   +1 more source

Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays

Vaccines, 2023
Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination.
Hiroaki Saito, Hiroki Yoshimura, Makoto Yoshida, Yuta Tani, Moe Kawashima, Taiga Uchiyama, Tianchen Zhao, Chika Yamamoto, Yurie Kobashi, Toyoaki Sawano, Seiya Imoto, Hyeongki Park, Naotoshi Nakamura, Shingo Iwami, Yudai Kaneko, Aya Nakayama, Tatsuhiko Kodama, Masatoshi Wakui, Takeshi Kawamura, Masaharu Tsubokura   +19 more
doaj   +1 more source

SnapShot: Broadly Neutralizing Antibodies

Cell, 2013
Durably elicited by live attenuated virus, less durably by inactivated virusConserved bnAb epitopes:1) Ep1 (res. 380–400) 2) Ep2 (res. 190–200)3) Ep3 (res. 571–579)Despite the extensive variability of measles virus, nAb responses to vaccination are broad becausethe conserved epitopes are immunoprominent.May relate to overlap of the receptor-binding ...
Brian Moldt, Devin Sok, Dennis R. Burton
openaire   +3 more sources

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

Viruses, 2012
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response.
Roberto Burioni, Laura Solforosi, Massimo Clementi, Roberta A. Diotti, Matteo Castelli, Elena Criscuolo, Nicola Clementi, Giuseppe Sautto, Mancini Nicasio   +8 more
doaj   +1 more source

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein.

PLoS Neglected Tropical Diseases, 2023
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
John M Powers, Zoe L Lyski, Whitney C Weber, Michael Denton, Magdalene M Streblow, Adam T Mayo, Nicole N Haese, Chad D Nix, Rachel Rodríguez-Santiago, Luisa I Alvarado, Vanessa Rivera-Amill, William B Messer, Daniel N Streblow   +12 more
doaj   +1 more source