Results 141 to 150 of about 300,221 (330)

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

COVID‐19: are neutralizing antibodies neutralizing enough? [PDF]

Transfusion, 2020
openaire   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Preparation and application of porcine broadly neutralizing monoclonal antibodies in an immunoassay for efficiently detecting neutralizing antibodies against foot-and-mouth disease virus serotype O

Microbiology Spectrum
Neutralizing antibodies provide vital protection against foot-and-mouth disease virus (FMDV). The virus neutralization test (VNT) is a gold standard method for the detection of neutralizing antibodies.
Yimei Cao, Fengjuan Li, Xiangchuan Xing, Huiyan Zhang, QiongQiong Zhao, Pu Sun, Yuanfang Fu, Pinghua Li, Xueqing Ma, Jing Zhang, Zhixun Zhao, Hong yuan, Jian Wang, Tao Wang, Huifang Bao, Xingwen Bai, Dong Li, Qiang Zhang, Kun Li, Zengjun Lu   +19 more
doaj   +1 more source

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

, 2020
David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Bret J. Musser, Yuhwen Soo, Diana Rofail, Joseph Im, Christina J. Perry, Cynthia X. Pan, Romana Hosain, Adnan Mahmood, John D. Davis, K. C. Turner, Andrea T. Hooper, Jennifer D. Hamilton, Alina Baum, Christos A. Kyratsous, Yun‐Ji Kim, Amanda Cook, Wendy Kampman, Anita Kohli, Yessica Sachdeva, Ximena Graber, Bari Kowal, Thomas DiCioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos   +32 more
openalex   +2 more sources

Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers [PDF]

, 2016
Kirsten Schneider-Ohrum, Corinne Cayatte, Yi Liu, Zhaoti Wang, Alivelu Irrinki, Floro Cataniag, Nga Nguyen, Stacie Lambert, Hui Liu, Shahin Aslam, G M Duke, Michael McCarthy, Louise McCormick   +12 more
openalex   +1 more source

Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting

Advanced Healthcare Materials, EarlyView.
Fibrillar bundles are introduced as a bioprintable additive that enables robust and scalable cellular alignment within 3D constructs through flow‐induced orientation during extrusion. These fibers support strong cell adhesion and polarization across various cell types and significantly enhance myotube alignment in Gelatine‐Methacryloyl (GelMA ...
Sven Heilig, Zan Lamberger, Lys Sprenger, Vivien Priebe, Camilla Mussoni, Denitsa Docheva, Kristina Andelovic, Jürgen Groll, Sahar Salehi, Gregor Lang, Matthias Ryma   +10 more
wiley   +1 more source

In vivo determination of protective antibody thresholds for SARS-CoV-2 variants using mouse models

Emerging Microbes and Infections
Neutralizing antibody titres have been shown to correlate with immune protection against COVID-19 and can be used to estimate vaccine effectiveness. Numerous studies have explored the relationship between neutralizing antibodies and protection.
Peilan Wei, Ruoxi Cai, Lu Zhang, Jingjun Zhang, Zhaoyong Zhang, Airu Zhu, Hai Li, Zhen Zhuang, Lan Chen, Jiantao Chen, Yuting Zhang, Xinyi Xiong, Bin Qu, Jianfen Zhuo, Tian Tang, Yuanyuan Zhang, Lei Chen, Qier Zhong, Zhiwei Lin, Xindan Xing, Fang Li, Qingtao Hu, Jun Dai, Yongxia Shi, Jingxian Zhao, Jincun Zhao, Yanqun Wang   +26 more
doaj   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Correction: A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2

, 2022
Gyoung Nyoun Kim, Jung-ah Choi, Kunyu Wu, Nasrin Saeedian, Eunji Yang, Hayan Park, Sun‐Je Woo, Gippeum Lim, Seong-Gyu Kim, Su-Kyeong Eo, Hoe Won Jeong, Taewoo Kim, Jae-Hyung Chang, Sang Hwan Seo, Na Hyung Kim, Eunsil Choi, Seungho Choo, Sangkyun Lee, Andrew Winterborn, Yue Li, Kate A. Parham, Justin M. Donovan, M. Brock Fenton, Jimmy D. Dikeakos, Gregory A. Dekaban, S. M. Mansour Haeryfar, Ryan M. Troyer, Eric J. Arts, Stephen D. Barr, Manki Song, C. Yong Kang   +30 more
openalex   +2 more sources