Results 31 to 40 of about 274,076 (393)

Somatic mutations and clonal hematopoiesis in congenital neutropenia.

Blood, 2018
Severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome (SDS) are congenital neutropenia syndromes with a high rate of leukemic transformation.
Jun Xia, Christopher A. Miller, J. Baty, Amrita Ramesh, M. Jotte, R. Fulton, T. Vogel, M. Cooper, K. Walkovich, Vahagn Makaryan, A. Bolyard, M. Dinauer, D. Wilson, A. Vlachos, K. Myers, R. Rothbaum, A. Bertuch, D. Dale, A. Shimamura, L. Boxer, D. Link   +20 more
semanticscholar   +1 more source

Clinical manifestations and outcomes of pediatric chronic neutropenia

Journal of the Formosan Medical Association, 2012
Neutropenia is a decrease in the number of circulating neutrophils. When neutropenia persists for more than 3 months, it becomes chronic. A heterogeneous group of diseases in children can cause chronic neutropenia.
Chuan Wan, Hsin-Hui Yu, Meng-Yao Lu, Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Yao-Hsu Yang, Bor-Luen Chiang   +7 more
doaj   +1 more source

Association between radioactive iodine uptake and neutropenia in untreated Graves’ disease

Endocrine Connections, 2023
Objective: Neutropenia is a complication of Graves' disease (GD), but there is currently no means by which to predict its occurrence. This study aimed to investigate the risk factors for the development of neutropenia in untreated GD. Methods: This was
Qian Yang, Wencai Ke, Fanfan Pan, Xinmei Huang, Jun Liu, Bingbing Zha   +5 more
doaj   +1 more source

Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study [PDF]

, 2006
Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and
Clamon G, Curran WJ, Fournel P, Furuse K, Gaspar LE, Gralla R, Gridelli C, Huber RM, Komaki R, Komaki R, Lester JF, Mamon HJ, Marino P, Nguyen L, Pignon JP, Pritchard RS, Sause W, Semrau S   +17 more
core   +1 more source

High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer [PDF]

, 2005
Background: Docetaxel is one of the most effective antitumor agents currently available for the treatment of metastatic breast cancer (MBC). This phase II multicenter study prospectively analyzed the efficacy and toxicity of docetaxel given on a weekly ...
Ajani JA, Ando M, B. Dorn, C. Jackisch, C. Kentenich, Chan S, Chevallier B, Dieras V, G. Deutsch, Hainsworth JD, Hudis CA, J. Papke, J. Stamp, J. Stemmler, Kaplan EL, M. Malekmohammadi, M. Stauch, Nabholtz JM, O. Brudler, S. Leinung, Salminen E, Trudeau ME, U. Vehling-Kaiser, V. Heinemann, Valero V, W. Abenhardt, W. Mair   +26 more
core   +1 more source

A meta-analysis of controlled studies comparing the association between clozapine and other antipsychotic medications and the development of neutropenia

Australian and New Zealand journal of psychiatry (Print), 2019
Background: In most countries, clozapine can only be prescribed with regular monitoring of white blood cell counts because of concerns that clozapine has a stronger association with neutropenia than other antipsychotics.
N. Myles, Hannah Myles, S. Xia, M. Large, R. Bird, C. Galletly, S. Kisely, D. Siskind   +7 more
semanticscholar   +1 more source

Near-universal hospitalization of US emergency department patients with cancer and febrile neutropenia [PDF]

, 2019
IMPORTANCE: Febrile neutropenia (FN) is the most common oncologic emergency and is among the most deadly. Guidelines recommend risk stratification and outpatient management of both pediatric and adult FN patients deemed to be at low risk of ...
Baugh, Christopher W., Camargo, Carlos A., Faridi, Mohammad Kamal, Mueller, Emily L., Pallin, Daniel J.   +4 more
core   +1 more source

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective

Pharmacogenomics (London), 2019
Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia.
S. Legge, J. Walters
semanticscholar   +1 more source

G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia

Haematologica, 2009
X-linked neutropenia (XLN) is a rare form of Congenital Neutropenia (CN) caused by inherited gain-of-function mutations of WAS. Here we report 2 cases of the original L270P X-linked neutropenia kindred that evolved to MDS or AML, with acquisition of G ...
Karolien Beel, Peter Vandenberghe
doaj   +1 more source

Neutropenia in Barth syndrome: characteristics, risks, and management

Current opinion in hematology, 2019
Purpose of review Barth syndrome (BTHS) is an X-linked disease characterized by defective remodeling of phospholipid side chains in mitochondrial membranes.
C. Steward, S. Groves, C. Taylor, M. Maisenbacher, B. Versluys, R. Newbury-Ecob, H. Ozsahin, Michaela Damin, Valerie M. Bowen, Katherine R. McCurdy, M. Mackey, A. Bolyard, D. Dale   +12 more
semanticscholar   +1 more source