Results 71 to 80 of about 220,141 (335)

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Neutropenia in children: clinical masks and therapeutic approach

Zdorovʹe Rebenka, 2018
Neutropenic syndrome is quite common in pediatric practice. Its nature is diverse, and every case of neutropenia needs thorough differential diagnosis to determine the patient’s management.
S.I. Ilchenko, O.S. Koreniuk, A.A. Fialkovskaya   +2 more
doaj   +1 more source

Efbemalenograstim alfa, an Fc fusion protein, long-acting granulocyte-colony stimulating factor for reducing the risk of febrile neutropenia following chemotherapy: results of a phase III trial [PDF]

, 2023
John A. Glaspy, Igor Bondarenko, Olga Burdaeva, Jianmin Chen, Dean Rutty, Renshu Li, Shufang Wang, Qingsong Hou, Simon Li   +8 more
openalex   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period.

PLoS ONE, 2019
For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried
Roberto L Parodi, Mariana Lagrutta, Mauro Tortolo, Estefanía Navall, María S Rodríguez, Gervasio F Sasia, Lucas F De Candia, Matias A Gruvman, Oscar Bottasso, Alcides A Greca   +9 more
doaj   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Neutropenia after intravenous immunoglobulin therapy is associated with coronary artery lesions in children with Kawasaki disease: a case control study

BMC Pediatrics, 2018
Background To evaluate differences in laboratory parameters, clinical presentation, and incidence of coronary artery lesions (CAL) between children with neutropenic and non-neutropenic Kawasaki disease (KD).
Zhenquan Wang, Fengfeng Weng, Chen Li, Hongying Shi, Zhangke Tang, Huixian Qiu, Yue’e He, Rongzhou Wu, Maoping Chu   +8 more
doaj   +1 more source

Serum cholesterol levels in neutropenic patients with fever [PDF]

, 2002
Hypocholesterolemia, which often accompanies infectious diseases has been suggested to serve as a prognostic marker in hospitalized patients. Even though patients with chemotherapyinduced leukopenia are at high risk of infection and mortality, only ...
Alvarez C, Bodey GP, Ettinger WH, Ettinger WH, Ettinger WH, Hermus R, Jacobs D, Pacelli F, Steinmetz HT, van Gameren MM, Werner M   +10 more
core   +1 more source

Exercise and Nutrition Prehabilitation Program During Preoperative Chemotherapy Followed by Esophagectomy in Older Patients With Esophageal Cancer: A Randomized Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
This prospective randomized trial evaluated whether prehabilitation, exercise and nutrition intervention, enhance skeletal muscle mass during neoadjuvant chemotherapy in older patients with esophageal cancer undergoing esophagectomy. We also investigated whether exercise alone was sufficient to increase skeletal muscle mass, and whether nutritional ...
Keijiro Sugimura, Takashi Kanemura, Tomohira Takeoka, Takahito Sugase, Norihiro Matsuura, Kazuyoshi Yamamoto, Masahiko Yano, Hiroshi Miyata   +7 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source