Results 301 to 310 of about 1,017,928 (387)

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2-CXCL1 Axis. [PDF]

Cells
Yoo H, Choi A, Kim M, Gye Y, Jo H, Kwok SK, Park Y, Lee JJ.   +7 more
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Eosinophil Dynamics as Prognostic Indicators in Immunotherapy for Pulmonary Lymphoepithelioma-Like Carcinoma. [PDF]

Cureus
Ho CYR, Cheung KM, Chow CHJ, Cheung GTC.
europepmc   +1 more source

Neutrophil products that inhibit cell proliferation: relation to granulocytic "chalone"

, 1978
SP Herman, DW Golde, MJ Cline
openalex   +1 more source

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Tracking NF-kB activity across steady-state neutrophil maturation. [PDF]

Cell Death Discov
Jeffries NE, Floyd DJ, Mei S, Sykes DB, Mansour MK.   +4 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury. [PDF]

Front Immunol
Cheng T, Xu Y, Liu Z, Wang Y, Zhang Z, Huang W.   +5 more
europepmc   +1 more source

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Science Translational Medicine, 2018
O. Wolach, R. Sellar, K. Martinod, Deya Cherpokova, M. McConkey, Ryan J. Chappell, A. Silver, Dylan N. Adams, Cecilia Castellano, R. Schneider, R. Padera, D. DeAngelo, M. Wadleigh, D. Steensma, I. Galinsky, R. Stone, G. Genovese, S. Mccarroll, Bozenna Iliadou, C. Hultman, D. Neuberg, A. Mullally, D. Wagner, B. Ebert   +23 more
semanticscholar   +1 more source