Results 81 to 90 of about 548,170 (252)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies

, 2020
The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function.
Joel Rasmuson (18654973)
core   +1 more source

Evaluation of the expression of matrix metalloproteinase 9 and neutrophil gelatinase associated lipocalin in serum, urine and tumoral tissues of female dogs suffering from mammary gland tumors [PDF]

, 2013
In human medicine, it has been shown recently that the level of expression of matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL) in serum, urine, and breast tissue were significantly increased in patients with breast
Belot, Guillaume
core  

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Neutrophil-Mediated Inflammation in Response to Acute Myocardial Infarction.

Neutrophils and neutrophil extracellular traps (NETs) are essential effectors of the innate immune system and are increasingly appreciated as drivers of various human pathologies.
Ceridwyn Jones (12986897)
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Neutrophil-Mediated Delivery of Nanocrystal Drugs via Photoinduced Inflammation Enhances Cancer Therapy

The efficient delivery of anticancer agents into tumor microenvironments is critical for the success of cancer therapies, but it is a prerequisite that drug carriers should overcome tumor vasculature and possess high drug contents.
Jin Gao (160559), Yujie Su (3920078), Xinyue Dong (6268559), Zhenjia Wang (552197), Kraig A. Wheeler (1541422)   +4 more
core   +4 more sources

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

Neutrophil-Membrane-Coated Biomineralized Metal–Organic Framework Nanoparticles for Atherosclerosis Treatment by Targeting Gene Silencing

, 2023
Antisense oligonucleotides (ASOs) are promising tools for gene silencing and have been exploited as therapeutics for human disease. However, delivery of therapeutic ASOs to diseased tissues or cells and subsequent escape from the endosomes and release of
Yi Liu (36759), Tong Zhang (103827), Kaiji Wei (15195437), Yi Yuan (180239), Mengyun He (6912455), Cunpeng Nie (6912458), Tingting Chen (111216), Xia Chu (12073)   +7 more
core   +1 more source