Results 81 to 90 of about 505,478 (313)

Redox processes are major regulators of leukotriene synthesis in neutrophils exposed to bacteria Salmonella typhimurium; the way to manipulate neutrophil swarming

Frontiers in Immunology
Neutrophils play a primary role in protecting our body from pathogens. When confronted with invading bacteria, neutrophils begin to produce leukotriene B4, a potent chemoattractant that, in cooperation with the primary bacterial chemoattractant fMLP ...
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Natalia D. Kondratenko, Tatjana V. Gaponova, Yulia M. Romanova, Konstantin G. Lyamzaev, Konstantin G. Lyamzaev, Boris V. Chernyak, Galina F. Sud’ina   +9 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Nonlinear association of the systemic immune-inflammatory index with mortality in diabetic patients

Frontiers in Endocrinology
BackgroundIt has been demonstrated that in diabetic patients, an elevated neutrophil-lymphocyte ratio (NLR) is independently connected with higher cardiovascular and all-cause mortality.
Chunli Meng, Kai Liu
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The dual role of neutrophils in sepsis-associated liver injury

Frontiers in Immunology
Sepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro- and anti ...
Lexin Fang, Yu Song, Jiangtao Chen, Yueping Ding   +3 more
doaj   +1 more source

Platelets in Skin Autoimmune Diseases

Frontiers in Immunology, 2019
Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis are three autoimmune diseases frequently manifested in the skin. They share common pathogenic features, including production of autoantibodies, loss of tolerance to
Xiaobo Liu, Xiaobo Liu, Christian Gorzelanny, Stefan W. Schneider   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Psychological stress and neutrophil function [PDF]

, 2011
Little is known about neutrophil function, an important component of innate immunity, in relation to psychosocial factors. This thesis investigated the effect of acute and chronic psychological stressors on human neutrophil function among young and ...
Suliman Khanfer, Riyad
core