Results 81 to 90 of about 688,534 (290)

Prefixation of Neutrophils for Neutrophil Antibody Testing [PDF]

Laboratory Medicine, 2014
The granulocyte immunofluorescence test based on flow cytometry is still the most commonly used method for detecting antineutrophil antibodies. We questioned whether neutrophil prefixation is necessary for this test.Three pretreatment methods using paraformaldehyde were compared: unfixed, short-fixed (3 minutes 40 seconds), and long-fixed (10 minutes ...
Ye Jee, Shim, Dong Il, Won
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Platelets in Skin Autoimmune Diseases

Frontiers in Immunology, 2019
Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis are three autoimmune diseases frequently manifested in the skin. They share common pathogenic features, including production of autoantibodies, loss of tolerance to
Xiaobo Liu, Xiaobo Liu, Christian Gorzelanny, Stefan W. Schneider   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

β-Hydroxybutyrate inhibits the spontaneous apoptosis of neutrophils through a degranulation–macrophage-1 antigen axis in cows with subclinical ketosis

Journal of Dairy Science
: Subclinical ketosis (SCK), a common metabolic disorder in dairy cows during the peripartum period, is accompanied by systemic inflammation and elevated circulating BHB.
Kexin Wang, Guowen Liu, Ke Zhang, Zhiyong Li, Yan Ren, Shang Jiang, Xiliang Du, Lin Lei, Wenwen Gao, Zhe Wang, Xinwei Li, Yuxiang Song   +11 more
doaj   +1 more source

Systemic inflammation: Cancer's long-distance reach to maximize metastasis [PDF]

, 2015
While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance ...
Coffelt, Seth B., de Visser, Karin E.
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Regenerative potential of immune cells after traumatic muscle injury

Frontiers in Immunology
Traumatic muscle injury (TMI) causes significant morbidity and socioeconomic burden. Immune cells are central to the subsequent regenerative response, orchestrating dynamic interactions between innate and adaptive immunity.
Su Pu, Guangmin Hu, Yulu Cao, Guoming Shen, Yuqing Wang   +4 more
doaj   +1 more source

Dynamic ROS Production and Gene Expression of Heifers Blood Neutrophil in a Oligofructose Overload Model

Frontiers in Veterinary Science, 2020
Alimentary oligofructose (OF) overload can induce several diseases in cattle, such as ruminal acidosis, laminitis, and synovitis. The role of blood polymorphonuclear neutrophil (PMN) remains unclear during OF overload.
Shuaichen Li, Shuaichen Li, Jiafeng Ding, Jiafeng Ding, Lihong Jiang, Lihong Jiang, Muhammad Abid Hayat, Muhammad Abid Hayat, Qiaozhi Song, Qiaozhi Song, Yuepeng Li, Yuepeng Li, Xianhao Zhang, Xianhao Zhang, Jiantao Zhang, Jiantao Zhang   +15 more
doaj   +1 more source