Results 71 to 80 of about 505,478 (313)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Neutrophil-Mediated Inflammation in Response to Acute Myocardial Infarction. [PDF]
Neutrophils and neutrophil extracellular traps (NETs) are essential effectors of the innate immune system and are increasingly appreciated as drivers of various human pathologies.
Ceridwyn Jones (12986897)
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Neutrophils in Psoriasis [PDF]
Frontiers in Immunology, 2019 Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting ~2-3% of the world population. The abundant presence of neutrophils in the psoriatic skin lesions serves as a typical histopathologic ...
Chih-Chao Chiang +15 more
openaire +3 more sources
La Revue de Médecine Interne, 2022 Neutrophilic dermatoses (ND) are a group of inflammatory skin conditions characterized by a neutrophilic infiltrate on histopathology with no evidence of infection. ND are classified based upon the localization of neutrophils within the skin and clinical features.
Delaleu, Jeremie +15 more
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
ROCK Inhibition Drives Resolution of Acute Inflammation by Enhancing Neutrophil Apoptosis
Cells, 2019 Uncontrolled inflammation leads to tissue damage and it is central for the development of chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely regulated by the action of anti-inflammatory and pro-resolutive mediators ...
Izabela Galvão +10 more
doaj +1 more source
Neutrophilic Thrombophagocytosis
Archives of Pathology & Laboratory Medicine, 2000 Abstract Thrombocytopenia as a complication of B-cell lymphoma usually results from the removal of platelets from the circulation by splenic and hepatic mononuclear phagocytes.1,2 In the present paper, we describe a case of B-cell lymphoma with thrombocytopenia in which the platelets were phagocytosed by the patient's own neutrophilic
J C, Lee, K, Tripathy
openaire +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Neutrophil-To-Lymphocyte Ratio as a Potential Biomarker of Neovascular Glaucoma [PDF]
, 2019 Purpose: To evaluate blood count–derived inflammation indexes as a detection or predictive marker for neovascular glaucoma (NVG) secondary to retinal vein occlusion (RVO) and diabetic retinopathy (DR).
Yingbo Ma (4783596) +7 more
core +1 more source