Results 71 to 80 of about 688,534 (290)

Redox processes are major regulators of leukotriene synthesis in neutrophils exposed to bacteria Salmonella typhimurium; the way to manipulate neutrophil swarming

Frontiers in Immunology
Neutrophils play a primary role in protecting our body from pathogens. When confronted with invading bacteria, neutrophils begin to produce leukotriene B4, a potent chemoattractant that, in cooperation with the primary bacterial chemoattractant fMLP ...
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Natalia D. Kondratenko, Tatjana V. Gaponova, Yulia M. Romanova, Konstantin G. Lyamzaev, Konstantin G. Lyamzaev, Boris V. Chernyak, Galina F. Sud’ina   +9 more
doaj   +1 more source

ROCK Inhibition Drives Resolution of Acute Inflammation by Enhancing Neutrophil Apoptosis

Cells, 2019
Uncontrolled inflammation leads to tissue damage and it is central for the development of chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely regulated by the action of anti-inflammatory and pro-resolutive mediators ...
Izabela Galvão, Rayssa M. Athayde, Denise A. Perez, Alesandra C. Reis, Luisa Rezende, Vivian Louise S. de Oliveira, Barbara M. Rezende, William A. Gonçalves, Lirlândia P. Sousa, Mauro M. Teixeira, Vanessa Pinho   +10 more
doaj   +1 more source

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Nonlinear association of the systemic immune-inflammatory index with mortality in diabetic patients

Frontiers in Endocrinology
BackgroundIt has been demonstrated that in diabetic patients, an elevated neutrophil-lymphocyte ratio (NLR) is independently connected with higher cardiovascular and all-cause mortality.
Chunli Meng, Kai Liu
doaj   +1 more source

Regulation of neutrophil senescence by microRNAs [PDF]

, 2011
Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants,
A Bonauer, A Lee, AD Kennedy, AS Cowburn, AW Ford-Hutchinson, C Haslett, C Martin, CH Wang, CL Andersen, DP Bartel, E Berezikov, E Tsitsiou, EP Cronkite, F Bazzoni, F Colotta, F Fazi, Frank R. DeLeo, GM Bokoch, H Su, H Xia, I Sabroe, I Sabroe, J Davidson-Moncada, J Savill, J Yu, James W. Catto, JB Johnnidis, JJ Lum, JL Mott, Jon R. Ward, JR Ward, LR Prince, M Merkerova, M Scherr, Marta Milo, MK Whyte, MK Whyte, Moira K. B. Whyte, OD Weiner, P Scapini, PA Davoren, Paul R. Heath, PT Nelson, R Chhabra, R Yi, RE Stringer, RW Watson, S Huang, S Radom-Aizik, S Slezak, SA Renshaw, SD Kobayashi, SD Kobayashi, Stephen A. Renshaw, W Filipowicz, W Huang da, WC Liles, WP Tsang, Y Lee, Y Wang, YZ Pan   +60 more
core   +5 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The dual role of neutrophils in sepsis-associated liver injury

Frontiers in Immunology
Sepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro- and anti ...
Lexin Fang, Yu Song, Jiangtao Chen, Yueping Ding   +3 more
doaj   +1 more source

The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae [PDF]

, 2017
Neutrophils play an important role in the innate immune response to infection with Streptococcus pneumoniae, the pneumococcus. Pneumococci are phagocytosed by neutrophils and undergo killing after ingestion.
Evans, Tom J., Ritchie, Neil D., Ullah, Ihsan   +2 more
core   +1 more source