Results 51 to 60 of about 688,534 (290)

Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis

Scientific Reports
Hashimoto’s Thyroiditis (HT) is an autoimmune disorder characterized by metabolic disturbances. However, a comprehensive metabolic and lipid profile of HT has not been reported.
Guoqiang Wang, Xuan Ye, Ting Lu, Yunxi Yang, Bingwei Sun, Hui Xiao   +5 more
doaj   +1 more source

Targeting Neutrophils in Sepsis: From Mechanism to Translation

Frontiers in Pharmacology, 2021
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of specific ...
Xiaofei Shen, Ke Cao, Yang Zhao, Junfeng Du, Junfeng Du, Junfeng Du   +5 more
doaj   +1 more source

Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility [PDF]

, 1996
When neutrophil leukocytes are stimulated by chemotactic factors or by substratum contact, they change their shape. Shape changes are a prerequisite for cellular migration and typically involve the extrusion of thin, veil-like lamellipods and the ...
Coates, Thomas D., Deranleau, David A., Ehrengruber, Markus U.   +2 more
core  

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. [PDF]

, 2016
Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications ...
Adibhatla, Agrawal, Alcaide, Amantea, Amantea, Anthony, Asahi, Asahi, Asahi, Bajor, Bakowski, Bauer, Benarroch, Burk, Candelario-Jalil, Carbone, Castellanos, Castellanos, Chang, Chesler, Choi, Clark, Clark, Conant, Copin, Cuadrado, Cuadrado, Cunningham, Dejonckheere, Fanjul-Fernández, Fernandez-Patron, Ferry, Fiorelli, Frank R. Sharp, Fujimoto, Fujimura, Fujimura, Gasche, Gasche, Gasche, Gautier, Gidday, Golab, Gu, Gurney, Gürsoy-Ozdemir, Hacke, Harris, Heo, Heo, Horstmann, Hu, Inzitari, Jickling, Justicia, Keck, Kelly, Khandoga, Kim, Kuroiwa, Kurzepa, Lapchak, Lee, Lenglet, Lenglet, Li, Lucivero, Lukes, Lynch, Machado, Maier, Manabe, McCarthy, Moldes, Montaner, Montaner, Montaner, Montaner, Montaner, Montaner, Mun-Bryce, Murata, Nguyen, Ning, Oda, Opdenakker, Orbe, Piccardi, Planas, Ra, Ramos-Fernandez, Ranasinghe, Renée J. Turner, Reynolds, Rivera, Rodrigues, Rodríguez, Rodríguez-Yáñez, Romanic, Rosell, Rosell, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sandoval, Schnoor, Shigemori, Si-Tayeb, Sotgiu, Steadman, Sternlicht, Sumii, Svedin, Tan, Tang, Tsuji, Tsuruoka, Turba, Van den Steen, Vandooren, Vukasovic, Wang, Wang, Wang, Yan, Yang, Yang, Yushchenko, Zhao, Zhao, Zhao, Zozulya   +133 more
core   +3 more sources

Neutrophils in Gliomas [PDF]

Frontiers in Immunology, 2017
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state.
Matteo Massara, Matteo Massara, Pasquale Persico, Ornella Bonavita, Ornella Bonavita, Valeria Mollica Poeta, Valeria Mollica Poeta, Massimo Locati, Massimo Locati, Matteo Simonelli, Matteo Simonelli, Raffaella Bonecchi, Raffaella Bonecchi   +12 more
openaire   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Korelasi Absolute Neutrophil Count Selama Kemoterapi dengan Kualitas Hidup pada Anak dengan Leukemia Limfoblastik Akut

Sari Pediatri
Latar belakang. Leukemia merupakan suatu penyakit keganasan sel darah yang berasal dari sumsum tulang. Toksisitas hematologi yang terjadi selama kemoterapi dapat memicu timbulnya perubahan neutrofil yang memunculkan manifestasi klinis sehingga menurunkan
Deta Putrimingtyas, Pridania Vidya, Muhammad Riza   +2 more
doaj   +1 more source

Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy [PDF]

, 2006
Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue.
Asimaki, A, Ebrahim, HY, Elliott, PM, Evans, A, Hitomi, N, McKenna, WJ, Norman, M, Pantazis, A, Sen-Chowdhry, S, Shaw, AL, Syrris, P, Ward, D   +11 more
core   +1 more source

Neutrophilic Thrombophagocytosis

Archives of Pathology & Laboratory Medicine, 2000
Abstract Thrombocytopenia as a complication of B-cell lymphoma usually results from the removal of platelets from the circulation by splenic and hepatic mononuclear phagocytes.1,2 In the present paper, we describe a case of B-cell lymphoma with thrombocytopenia in which the platelets were phagocytosed by the patient's own neutrophilic ...
J C, Lee, K, Tripathy
openaire   +2 more sources

Heterogeneity Among Neutrophils [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2017
Neutrophils (PMNs) play a key role in innate defence mechanisms. Generally, PMNs were considered to have a homogeneous population of mature and diversified cells. It seems, however, that their pleiotropic action results from the existence of different subpopulations in this group of cells.
Garley, Marzena, Jabłońska, Ewa
openaire   +3 more sources