Results 31 to 40 of about 416,964 (269)

Three-dimensional migration of neutrophils through an electrospun nanofibrous membrane

BioTechniques, 2015
The study of immune cell migration is important for understanding the immune system network, which is associated with the response to foreign cells. Neutrophils act against foreign cells before any other immune cell, and they must be able to change shape
Songwan Jin, Tae-Min Park, Cho-Hee Kim, Jin-Soo Kim, Binh Duong Le, Young Hun Jeong, Jong-Young Kwak, Sik Yoon   +7 more
doaj   +1 more source

Neutrophil Activated by the Famous and Potent PMA (Phorbol Myristate Acetate)

Cells, 2022
This review will briefly outline the major signaling pathways in PMA-activated neutrophils. PMA is widely used to understand neutrophil pathways and formation of NETs.
Hylane Luiz Damascena, Wendy Ann Assis Silveira, Mariana S. Castro, Wagner Fontes   +3 more
doaj   +1 more source

Dynamic CD177/CD10 ratio for infection diagnosis and mortality risk stratification in critically ill patients: a prospective cohort studyResearch in context

EBioMedicine
Summary: Background: Two crucial needs persist in delivering effective critical care: reliable differentiation of infectious vs non-infectious systemic inflammation and detection of impending sepsis before the occurrence of organ dysfunction.
Jiamin Huang, Keliang Xie, Heyue Li, Xiao Wen, Yiwen Mei, Jiahui Chen, Aixiang Yang, Bingwei Sun   +7 more
doaj   +1 more source

A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model

Biomolecules, 2022
Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H2O2 to form several degradation products, some of which have been detected in vivo and may contribute to the ...
Fei-Fei Yu, Yao Yuan, Yan Ao, Li Hua, Wu Wang, Yiyi Cao, Jing Xi, Yang Luan, Shangwei Hou, Xin-Yu Zhang   +9 more
doaj   +1 more source

Neutrophil chemotaxis score and chemotaxis-related genes have the potential for clinical application to prognosticate the survival of patients with tumours

BMC Cancer
As frontline cells, the precise recruitment of neutrophils is crucial for resolving inflammation and maintaining the homeostasis of the organism. Increasing evidence suggests the pivotal role of neutrophil chemotaxis in cancer progression and metastasis.
Yunxi Yang, Jun Yang, Linbin Li, Yiming Shao, Lu Liu, Bingwei Sun   +5 more
doaj   +1 more source

Reliable genetic diagnosis of NCF1 (p47phox)-deficient chronic granulomatous disease using high-throughput sequencing

Frontiers in Immunology
IntroductionChronic granulomatous disease is caused by mutations in any of the 6 components of the phagocytic NADPH oxidase complex including gp91phox, p47phox, p22phox, p40phox, p67phox, or EROS.
Amy P. Hsu, Eric Karlins, Justin Lack, Justin Lack, T. Joseph Pepper, Karen Lau, Kimberly R. Marshall-Batty, Debra Long Priel, Joie Davis, Danielle L. Fink, Christa S. Zerbe, John I. Gallin, Harry L. Malech, Steven M. Holland, Douglas B. Kuhns   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Cell Transplantation
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies.
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun   +6 more
doaj   +1 more source

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified into eosinophilic asthma, neutrophilic asthma, neutrophilic and eosinophilic asthma, and ...
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source